Schulze-Späte Ulrike, Wurschi Ludwig, van der Vorst Emiel P C, Hölzle Frank, Craveiro Rogerio B, Wolf Michael, Noels Heidi
Section of Geriodontics, Department of Conservative Dentistry and Periodontics, University Hospital Jena, Jena, Germany.
Institute for Molecular Cardiovascular Research (IMCAR), Uniklinik RWTH Aachen, RWTH Aachen University, Aachen, Germany.
Front Immunol. 2024 Dec 9;15:1469077. doi: 10.3389/fimmu.2024.1469077. eCollection 2024.
Recent demographic developments resulted in an aged society with a rising disease burden of systemic and non-communicable diseases (NCDs). In cardiovascular disease (CVD), a NCD with high morbidity and mortality, recent preventive strategies include the investigation of comorbidities to reduce its significant economic burden. Periodontal disease, an oral bacterial-induced inflammatory disease of tooth-supporting tissue, is regulated in its prevalence and severity by the individual host response to a dysbiotic oral microbiota. Clinically, both NCDs are highly associated; however, shared risk factors such as smoking, obesity, type II diabetes mellitus and chronic stress represent only an insufficient explanation for the multifaceted interactions of both disease entities. Specifically, the crosstalk between both diseases is not yet fully understood. This review summarizes current knowledge on the clinical association of periodontitis and CVD, and elaborates on how periodontitis-induced pathophysiological mechanisms in patients may contribute to increased cardiovascular risk with focus on atherosclerosis. Clinical implications as well as current and future therapy considerations are discussed. Overall, this review supports novel scientific endeavors aiming at improving the quality of life with a comprehensive and integrated approach to improve well-being of the aging populations worldwide.
近期的人口发展趋势导致社会老龄化，系统性和非传染性疾病（NCDs）的疾病负担不断增加。在心血管疾病（CVD）这种发病率和死亡率都很高的非传染性疾病中，近期的预防策略包括对合并症进行调查，以减轻其巨大的经济负担。牙周病是一种由口腔细菌引起的牙齿支持组织的炎症性疾病，其患病率和严重程度受个体宿主对失调口腔微生物群的反应调节。临床上，这两种非传染性疾病高度相关；然而，吸烟、肥胖、II型糖尿病和慢性应激等共同风险因素，对于这两种疾病实体的多方面相互作用来说，只是一个不充分的解释。具体而言，这两种疾病之间的相互作用尚未完全明了。本综述总结了目前关于牙周炎与心血管疾病临床关联的知识，并阐述了牙周炎在患者中引发的病理生理机制如何导致心血管风险增加，重点是动脉粥样硬化。文中还讨论了临床意义以及当前和未来的治疗考量。总体而言，本综述支持旨在通过全面综合的方法提高全球老龄化人口福祉、改善生活质量的新科学努力。
