Wang Changbing, Yang Yujie, Wu Kaixuan, Wang Chenyang, Liu Wenkuan, Zhu Yuhui, Ye Lihua, Li Xiao, Zhou Rong, Zhu Bing, Tian Xingui
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, People's Republic of China.
Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China.
J Med Virol. 2024 Dec;96(12):e70139. doi: 10.1002/jmv.70139.
Human adenovirus (HAdV) is an important pathogen causing pediatric acute respiratory illness (ARI) before COVID-19 pandemic. Since January 2023, China has reported ARI outbreaks attributed to Mycoplasma pneumoniae and other respiratory viruses. In this study, a total of 276 737 pediatric patients with ARI were enrolled from January 2023 to April 2024. HAdV-positive samples were identified by real-time PCR. The monthly frequency of HAdV infection remained below 0.9% through July 2023, with a gradual rise to 1.03% in November and 2.92% in December. A significant surge was observed in the early months of 2024, with HAdV-positive rate spiking to 10.81% (3025/27992) in January and 10.75% (1393/12954) in February. The adenovirus outbreak peaked during the third to fifth week of 2024, with the highest recorded ratio of 23.86% (131/549) on January 29, 2024. Among the 600 samples that were typed, the predominant subtypes were HAdV-B3 (96%) and HAdV-C1 (2.67%). Phylogenetic analysis of two HAdV-B3 strains revealed close genomic similarity to the strain BJ20170281, which was isolated in Beijing, China, in 2017. HAdV-B3 has triggered an outbreak in Southern China in winter, an atypical epidemic season, following the COVID-19 pandemic. Ongoing surveillance of circulating pathogens including HAdV is necessary to prevent ARI outbreaks.
人腺病毒（HAdV）是在新冠疫情大流行之前导致儿童急性呼吸道疾病（ARI）的重要病原体。自2023年1月以来，中国报告了由肺炎支原体和其他呼吸道病毒引起的ARI疫情。在本研究中，共纳入了2023年1月至2024年4月期间的276737例ARI儿童患者。通过实时PCR鉴定HAdV阳性样本。截至2023年7月，HAdV感染的月度频率一直低于0.9%，11月逐渐上升至1.03%，12月为2.92%。2024年初观察到显著激增，1月HAdV阳性率飙升至10.81%（3025/27992），2月为10.75%（1393/12954）。腺病毒疫情在2024年第三至第五周达到高峰，2024年1月29日记录的最高比例为23.86%（131/549）。在600份分型样本中，主要亚型为HAdV-B3（96%）和HAdV-C1（2.67%）。对两株HAdV-B3菌株的系统发育分析显示，其基因组与2017年在中国北京分离的BJ-20170281菌株密切相似。新冠疫情大流行之后，HAdV-B3在冬季这一非典型流行季节引发了中国南方的疫情。持续监测包括HAdV在内的循环病原体对于预防ARI疫情是必要的。
