Solovev I A, Golubev D A
Pitirim Sorokin Syktyvkar State University, Medical Institute, Laboratory of Translational bioinformatics and systems biology, Syktyvkar, Russia.
Biomed Khim. 2024 Dec;70(6):381-393. doi: 10.18097/PBMC20247006381.
The review summarizes recent achievements and future prospects in the use of chronobiotics for regulating circadian rhythms regulation. Special attention is paid to the mechanisms' action, their classification, and the impact of chemical interventions on the biological clock. Chronobiotics defined as a diverse group of compounds capable of restoring disrupted circadian functions, addressing challenges such as irregular work schedules, artificial light exposure or ageing. The review categorizes these compounds by their pharmacological effects, molecular targets, and chemical structures, underlining their ability to enhance or inhibit key circadian components like CLOCK, BMAL1, PER, and CRY. A particular focus is placed on the therapeutic applications of chronobiotics, including their potential for treating sleep disorders, metabolic issues, and age-related rhythm disturbances, underscoring their wide-ranging applicability in health care. Chronobiotic compounds have promising roles in maintaining physiological rhythms, supporting healthy aging, and enhancing personalised health care. Given their diverse therapeutic potential, chronobiotics are positioned as a significant avenue for further clinical application, marking them as a crucial area of ongoing research and innovation.
这篇综述总结了使用时间生物学剂调节昼夜节律的最新成果和未来前景。特别关注了其作用机制、分类以及化学干预对生物钟的影响。时间生物学剂被定义为一类能够恢复紊乱的昼夜功能的多种化合物，可应对诸如不规律的工作时间表、人工光照暴露或衰老等挑战。该综述根据这些化合物的药理作用、分子靶点和化学结构对其进行分类，强调它们增强或抑制诸如CLOCK、BMAL1、PER和CRY等关键昼夜节律成分的能力。特别关注了时间生物学剂的治疗应用，包括其治疗睡眠障碍、代谢问题和与年龄相关的节律紊乱的潜力，突出了它们在医疗保健中的广泛适用性。时间生物学化合物在维持生理节律、支持健康衰老和加强个性化医疗保健方面具有前景。鉴于其多样的治疗潜力，时间生物学剂被定位为进一步临床应用的重要途径，使其成为正在进行的研究和创新的关键领域。
