Akgun N, Sofiyeva N, Yalcın P B, Laganà A S, Oral E
Facts Views Vis Obgyn. 2024 Dec;16(4):409-428. doi: 10.52054/FVVO.16.4.046.
Current evidence on the role of macro- and micronutrients in the aetiopathogenesis of endometriosis is controversial.
In this systematic review, we aimed to investigate the effect of macronutrients, dairy products, fruits, and vegetables on the occurrence and progression of endometriosis.
A systematic literature review of eligible articles retrieved from medical databases, including PubMed, Cochrane, and Academic Search, was performed from inception to May 2023.
The role of nutritional diet effects in endometriosis.
Our search yielded 12 studies, including five prospective cohort trials and seven case-control studies. The analysis of this literature supports the idea that processed and unprocessed red meat increases the risk of endometriosis, while no conclusive evidence exists about the effects of other protein sources on the disease. Studies on total fat consumption, including monounsaturated, polyunsaturated, saturated, and trans-unsaturated fats, do not suggest a definitive association with endometriosis. Green leafy vegetables and fresh fruit consumption may reduce the risk of endometriosis. Furthermore, the evidence regarding fibre consumption is not conclusive. Dairy products were found to have a risk-reducing effect on the disease. However, there was no consensus about the role of vitamin D in endometriosis.
The certainty of the relationship between endometriosis and outcomes of nutritional factors was "very low" to "low," which limits current literature from being applied for conclusive interpretations. Further large-scale randomised trials and consequent meta-analyses are recommended for high-level evidence.
WHAT IS NEW?: This article presents an overview of evidence-based studies on the relationship between endometriosis and macronutrients. In addition, the possible influence of other nutritional variables on the development of endometriosis and the limitations of nutritional studies.
关于大量营养素和微量营养素在子宫内膜异位症病因发病机制中的作用，目前的证据存在争议。
在本系统评价中，我们旨在研究大量营养素、乳制品、水果和蔬菜对子宫内膜异位症发生和进展的影响。
对从医学数据库（包括PubMed、Cochrane和学术搜索）检索到的符合条件的文章进行了从起始到2023年5月的系统文献综述。
营养饮食对子宫内膜异位症的影响作用。
我们的检索得到12项研究，包括5项前瞻性队列试验和7项病例对照研究。对这些文献的分析支持以下观点：加工和未加工的红肉会增加子宫内膜异位症的风险，而关于其他蛋白质来源对该疾病的影响尚无确凿证据。关于总脂肪摄入量的研究，包括单不饱和脂肪、多不饱和脂肪、饱和脂肪和反式不饱和脂肪，并未表明与子宫内膜异位症有明确关联。食用绿叶蔬菜和新鲜水果可能会降低子宫内膜异位症的风险。此外，关于膳食纤维摄入的证据尚无定论。发现乳制品对该疾病有降低风险的作用。然而，关于维生素D在子宫内膜异位症中的作用尚无共识。
子宫内膜异位症与营养因素结果之间关系的确定性为“非常低”到“低”，这限制了当前文献用于确凿解释。建议进行进一步的大规模随机试验及后续的荟萃分析以获得高级别证据。
新内容是什么？：本文概述了关于子宫内膜异位症与大量营养素之间关系的循证研究。此外，还介绍了其他营养变量对子宫内膜异位症发展的可能影响以及营养研究的局限性。
