Masaoka S, Lev-Ran A, Hill L R, Vakil G, Hon E H
Diabetes Care. 1985 Jan-Feb;8(1):64-8. doi: 10.2337/diacare.8.1.64.
Heart rate variability (HRV) during deep breathing was studied with a neonatal heart monitor in 143 control subjects and 218 patients with diabetes (102 with IDDM and 116 with NIDDM). In the control group HRV decreased after age 20 by 4-5 beats per decade (from 29.7 +/- 5.8 beats at age 20-29 to 11.8 +/- 5.4 beats at age 60+). In all age groups HRV in IDDM was lower than in the controls, and both age and duration of diabetes played a role in the decrease of HRV (from 21.5 +/- 5.3 beats at age 20-29 to 6.3 +/- 5.4 at age 60+). In NIDDM aging seemed to play a less important role, and the influence of the duration of the disease was not statistically significant. In both groups of patients the frequency of HRV below the 2.5th percentile was 82% in those with symptoms and/or signs of autonomic neuropathy, 64% in patients with peripheral neuropathy only, and 36% in those who had no obvious signs or symptoms of neuropathy. Interindividual variability was pronounced, and age and duration of the disease together accounted for only 36% of the observed differences between IDDM and the controls. Determination of HRV with a standard neonatal heart monitor presents an easy, simple, and nonstressful test of cardiac autonomic neuropathy. The norms of the test are age related.
采用新生儿心脏监测仪对143名对照者和218例糖尿病患者（102例胰岛素依赖型糖尿病患者和116例非胰岛素依赖型糖尿病患者）进行了深呼吸时心率变异性（HRV）的研究。在对照组中，20岁以后HRV每十年下降4 - 5次/分钟（从20 - 29岁时的29.7±5.8次/分钟降至60岁以上时的11.8±5.4次/分钟）。在所有年龄组中，胰岛素依赖型糖尿病患者的HRV均低于对照组，且糖尿病的年龄和病程均对HRV下降有影响（从20 - 29岁时的21.5±5.3次/分钟降至60岁以上时的6.3±5.4次/分钟）。在非胰岛素依赖型糖尿病中，年龄似乎起的作用较小，且疾病病程的影响无统计学意义。在两组患者中，HRV低于第2.5百分位数的频率在有自主神经病变症状和/或体征的患者中为82%，仅患有周围神经病变的患者中为64%，而无明显神经病变体征或症状的患者中为36%。个体间差异明显，年龄和疾病病程共同仅占胰岛素依赖型糖尿病患者与对照组之间观察到差异的36%。使用标准新生儿心脏监测仪测定HRV是一种简单、易行且无应激的心脏自主神经病变检测方法。该检测的正常范围与年龄相关。
