Ye Bingyu, Yue Meijuan, Chen Hu, Sun Caifang, Shao Yongle, Jin Qinpeng, Zhang Chunyan, Yu Guoying
State Key Laboratory of Cell Differentiation and Regulation, College of Life Sciences, Henan Normal University, Xinxiang, 453007, China.
Anyang Food and Drug Inspection and Testing Center, Anyang, 455000, China.
Mol Biol Rep. 2024 Dec 24;52(1):78. doi: 10.1007/s11033-024-10177-5.
Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are key downstream effectors of the Hippo pathway that regulate organ size, tissue homeostasis, and cancer development. YAP/TAZ play crucial regulatory roles in organ growth, cell proliferation, cell renewal, and regeneration. Mechanistically, YAP/TAZ influence the occurrence and progression of liver regeneration (LR) through various signaling pathways, including Notch, Wnt/β-catenin, TGF-β/Smad. While the activation of YAP/TAZ can promote the regeneration of damaged liver tissue, their mechanisms of action may differ under various LR conditions. Furthermore, excessive activation of YAP/TAZ may also lead to severe liver damage, manifesting as alcoholic hepatitis, liver fibrosis, and even liver cancer. Here, we review the role and mechanisms of YAP/TAZ in LR and liver disease, highlighting the potential for advancements in clinical diagnosis and treatment targeting YAP/TAZ in these contexts.
Yes相关蛋白（YAP）和具有PDZ结合基序的转录共激活因子（TAZ）是Hippo信号通路的关键下游效应因子，可调节器官大小、组织稳态和癌症发展。YAP/TAZ在器官生长、细胞增殖、细胞更新和再生中发挥关键的调节作用。从机制上讲，YAP/TAZ通过多种信号通路影响肝再生（LR）的发生和进展，包括Notch、Wnt/β-连环蛋白、TGF-β/Smad。虽然YAP/TAZ的激活可以促进受损肝组织的再生，但它们在不同LR条件下的作用机制可能不同。此外，YAP/TAZ的过度激活也可能导致严重的肝损伤，表现为酒精性肝炎、肝纤维化，甚至肝癌。在此，我们综述了YAP/TAZ在LR和肝脏疾病中的作用及机制，强调了在这些情况下针对YAP/TAZ进行临床诊断和治疗的潜在进展。
