Central Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, People's Republic of China.
Faculty of Science and Technology, Sunway University, Selangor Darul Ehsan, Malaysia.
Cell Mol Life Sci. 2021 Jan;78(2):497-512. doi: 10.1007/s00018-020-03579-8. Epub 2020 Aug 3.
YAP and TAZ are ubiquitously expressed homologous proteins originally identified as penultimate effectors of the Hippo signaling pathway, which plays a key role in maintaining mammalian tissue/organ size. Presently, it is known that YAP/TAZ also interact with various non-Hippo signaling pathways, and have diverse roles in multiple biological processes, including cell proliferation, tissue regeneration, cell lineage fate determination, tumorigenesis, and mechanosensing. In this review, we first examine the various microenvironmental cues and signaling pathways that regulate YAP/TAZ activation, through the Hippo and non-Hippo signaling pathways. This is followed by a brief summary of the interactions of YAP/TAZ with TEAD1-4 and a diverse array of other non-TEAD transcription factors. Finally, we offer a critical perspective on how increasing knowledge of the regulatory mechanisms of YAP/TAZ signaling might open the door to novel therapeutic applications in the interrelated fields of biomaterials, tissue engineering, regenerative medicine and synthetic biology.
YAP 和 TAZ 是广泛表达的同源蛋白，最初被鉴定为 Hippo 信号通路的倒数第二个效应物，该通路在维持哺乳动物组织/器官大小方面起着关键作用。目前已知，YAP/TAZ 还与各种非 Hippo 信号通路相互作用，并在多种生物学过程中发挥多种作用，包括细胞增殖、组织再生、细胞谱系命运决定、肿瘤发生和机械感知。在这篇综述中，我们首先研究了通过 Hippo 和非 Hippo 信号通路调节 YAP/TAZ 激活的各种微环境线索和信号通路。接下来，我们简要总结了 YAP/TAZ 与 TEAD1-4 以及各种其他非 TEAD 转录因子的相互作用。最后，我们从批判性的角度探讨了增加对 YAP/TAZ 信号转导调控机制的认识如何为生物材料、组织工程、再生医学和合成生物学等相互关联的领域中的新型治疗应用开辟道路。
