Nagy E, Friesen H G, Sehon A H, Berczi I
Endocrinology. 1985 Mar;116(3):1117-22. doi: 10.1210/endo-116-3-1117.
The effect on the immune response of the MtT/W5 (W5), MtT/W10 (W10) tumors of Wistar-Furth rats and of MtT/F4 (F4) tumor transplantable in Fischer 344 rats was examined. Antibody response to sheep red blood cells and contact sensitivity reactions to dinitrochlorobenzene (DNCB) were used as immune parameters. In intact rats the W5 tumor suppressed the antibody response as much as did hypophysectomy (Hypox). The antibody response of Hypox rats was marginally improved by this tumor. Contact sensitivity was not suppressed in intact animals and the poor reactivity of Hypox rats was reconstituted to normal levels by W5. Treatment with bromocriptine (BRC) had no influence on tumor growth or on the immune reactivity of tumor-bearing hosts. The W10 tumor suppressed antibody formation, but not contact sensitivity in intact animals; the antibody and the DNCB response of Hypox animals was reconstituted partially, by this tumor. BRC treatment of tumor-bearing animals mimicked the effect of Hypox in this system. The F4 tumor suppressed antibody formation in intact rats and did not reconstitute the reactivity of Hypox rats. The DNCB response was not influenced by this tumor in intact animals and it was partially reconstituted in Hypox rats. Again, the reactivity of BRC-treated animals was similar to that of Hypox tumor-bearing animals. These results indicate that pituitary tumors may alter the immune reactivity of their hosts significantly.
研究了Wistar-Furth大鼠的MtT/W5（W5）、MtT/W10（W10）肿瘤以及可移植于Fischer 344大鼠的MtT/F4（F4）肿瘤对免疫反应的影响。以对绵羊红细胞的抗体反应和对二硝基氯苯（DNCB）的接触敏感性反应作为免疫参数。在未切除垂体的大鼠中，W5肿瘤对抗体反应的抑制程度与垂体切除（Hypox）相当。该肿瘤使垂体切除大鼠的抗体反应略有改善。在未切除垂体的动物中，接触敏感性未受抑制，W5使垂体切除大鼠的低反应性恢复到正常水平。用溴隐亭（BRC）治疗对肿瘤生长或荷瘤宿主的免疫反应性均无影响。W10肿瘤抑制抗体形成，但在未切除垂体的动物中不抑制接触敏感性；该肿瘤使垂体切除动物的抗体和DNCB反应部分恢复。对荷瘤动物进行BRC治疗在该系统中模拟了垂体切除的效果。F4肿瘤抑制未切除垂体大鼠的抗体形成，且未恢复垂体切除大鼠的反应性。在未切除垂体的动物中，该肿瘤不影响DNCB反应，而在垂体切除大鼠中使其部分恢复。同样，经BRC治疗的动物的反应性与荷垂体切除肿瘤动物的反应性相似。这些结果表明垂体肿瘤可能会显著改变其宿主的免疫反应性。
