Colle E, Guttmann R D, Seemayer T A
Endocrinology. 1985 Apr;116(4):1243-7. doi: 10.1210/endo-116-4-1243.
Overt insulin-dependent diabetes mellitus in the rat is associated with the u haplotype of the rat major histocompatibility complex (MHC), RT1. Thyroiditis of sufficient severity to result in elevation of TSH levels is seen in Buffalo rats (RT1b). In order to examine the association of autoimmune thyroid disease with MHC gene products, we have crossed inbred Buffalo rats with diabetic BB rats and examined the RT1 genotype, the histology of thyroid and pancreatic tissue, and two indices of thyroid function. The data indicate that animals having pancreatic lymphocytic infiltration and insulinopenic overt diabetes mellitus had at least one RT1u haplotype. All but one animal having severe histological thyroid lymphocytic infiltration had at least one RT1b haplotype. Rats with severe thyroiditis had higher mean TSH levels than rats with normal histology or rats with mild thyroiditis. We conclude that gene products of the rat MHC affect the severity of spontaneous organ-specific autoimmune disease in terms of clinically apparent as well as tissue inflammatory disease.
大鼠显性胰岛素依赖型糖尿病与大鼠主要组织相容性复合体（MHC）RT1的u单倍型相关。在布法罗大鼠（RT1b）中可见严重程度足以导致促甲状腺激素（TSH）水平升高的甲状腺炎。为了研究自身免疫性甲状腺疾病与MHC基因产物的关联，我们将近交系布法罗大鼠与糖尿病BB大鼠进行杂交，并检测了RT1基因型、甲状腺和胰腺组织的组织学以及两项甲状腺功能指标。数据表明，患有胰腺淋巴细胞浸润和胰岛素缺乏型显性糖尿病的动物至少有一个RT1u单倍型。除一只动物外，所有患有严重组织学甲状腺淋巴细胞浸润的动物至少有一个RT1b单倍型。患有严重甲状腺炎的大鼠的平均TSH水平高于组织学正常或患有轻度甲状腺炎的大鼠。我们得出结论，大鼠MHC的基因产物在临床明显疾病以及组织炎症性疾病方面会影响自发性器官特异性自身免疫性疾病的严重程度。
