PKMζ: A Brain Kinase Driving Metabolic Reprogramming and Myofibroblastic Differentiation.
作者信息
Filliol Aveline
机构信息
Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York.
出版信息
Cell Mol Gastroenterol Hepatol. 2025;19(3):101437. doi: 10.1016/j.jcmgh.2024.101437. Epub 2025 Jan 16.
Abstract
摘要
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本文引用的文献
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PKMζ, a Brain-specific PKCζ Isoform, is Required for Glycolysis and Myofibroblastic Activation of Hepatic Stellate Cells.PKMζ是一种大脑特异性蛋白激酶Cζ亚型，是肝星状细胞糖酵解和肌成纤维细胞激活所必需的。
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Targeting Src SH3 domain-mediated glycolysis of HSC suppresses transcriptome, myofibroblastic activation, and colorectal liver metastasis.靶向 HSC 中Src SH3 结构域介导的糖酵解抑制转录组、肌成纤维细胞激活和结直肠肝转移。
Hepatology. 2024 Sep 1;80(3):578-594. doi: 10.1097/HEP.0000000000000763. Epub 2024 Jan 24.
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Fibroblasts in liver cancer: functions and therapeutic translation.肝癌中的成纤维细胞：功能与治疗学转化。
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Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts.肿瘤受到 I 型胶原的限制，可对抗癌症相关成纤维细胞的促肿瘤作用。
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Targeting cell-intrinsic metabolism for antifibrotic therapy.靶向细胞内在代谢进行抗纤维化治疗。
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