Spinola Sandra Gouveia, Sobral Ana Paula Taboada, Mandetta Amanda Rafaelly Honório, Gimenez Thais, Gonçalves Marcela Letícia Leal, Soares Paulo Vinícius, Santos Elaine Marcilio, Imparato José Carlos Pettorossi, Horliana Anna Carolina Ratto Tempestini, Mesquita-Ferrari Raquel Agnelli, Motta Lara Jansiski, Fernandes Kristianne Porta Santos, Bussadori Sandra Kalil
Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho, São Paulo, São Paulo, Brazil.
Postgraduation Program in Health and Environment, Universidade Metropolitana de Santos, Santos, São Paulo, Brazil.
BMJ Open. 2024 Dec 23;14(12):e090085. doi: 10.1136/bmjopen-2024-090085.
Childhood early oral ageing syndrome (CEOAS) is a condition involving oral abnormalities resulting from systemic diseases of different origins that are related to the current lifestyle of the paediatric population. Enamel defects associated with intrinsic and extrinsic factors promote the early loss of tooth structure at an accelerated pace, with negative impacts on function, aesthetics and quality of life. The aim of the study is to identify the prevalence of early tooth wear in childhood and its severity using the CEOAS index, which is a tool for the diagnosis of the condition and for epidemiological surveys, involving the investigation of abnormalities of the oral cavity in the paediatric population and possible factors associated with the severity of the condition.
Children aged 3-6 years will be recruited from the paediatric clinic of Universidade Nove de Julho. Children with amelogenesis imperfecta, dentinogenesis imperfecta and genetic syndromes, as well as those undergoing orthodontic treatment will be excluded. A questionnaire will be administered addressing general health, sleep quality, dietary habits, oral hygiene habits and parafunctional habits. Clinical examinations will then be performed using the novel CEOAS index to assess tooth wear (scores 0-3) and determine the occurrence of enamel defects (scores I-III). The vertical dimension of occlusion (VDO) will also be measured. The CEOAS scores will be computed for the deciduous dentition and analysed statistically, with the significance level set at 5% (p<0.05).
This protocol has been approved by the institutional review board of Universidade Nove de Julho (process number: 6.713.724. Approved on 20 March 2024). The results will be submitted to international peer-reviewed journals and presented at international conferences.
www.
gov, NCT06381414. Registered 23 April 2024.
儿童早期口腔衰老综合征（CEOAS）是一种由不同起源的全身性疾病引起的口腔异常状况，这些疾病与儿童群体当前的生活方式有关。与内在和外在因素相关的牙釉质缺陷会加速牙齿结构的早期丧失，对功能、美观和生活质量产生负面影响。本研究的目的是使用CEOAS指数确定儿童早期牙齿磨损的患病率及其严重程度，该指数是一种用于诊断该病症和进行流行病学调查的工具，涉及对儿童群体口腔异常情况以及与病症严重程度相关的可能因素的调查。
将从七月九日大学儿科诊所招募3至6岁的儿童。患有釉质发育不全、牙本质发育不全和遗传综合征的儿童，以及正在接受正畸治疗的儿童将被排除。将发放一份问卷，询问一般健康状况、睡眠质量、饮食习惯、口腔卫生习惯和副功能习惯。然后使用新颖的CEOAS指数进行临床检查，以评估牙齿磨损情况（0至3分）并确定牙釉质缺陷的发生情况（I至III分）。还将测量咬合垂直距离（VDO）。将计算乳牙列的CEOAS分数并进行统计分析，显著性水平设定为5%（p<0.05）。
本方案已获得七月九日大学机构审查委员会的批准（程序编号：6.713.724。于2024年3月20日批准）。研究结果将提交给国际同行评审期刊，并在国际会议上发表。
www.
gov，NCT06381414。于2024年4月23日注册。
