It is time to reevaluate the lard in glucose homeostasis and diabetes pathogenesis.

Most modern dietary guidelines recommend limiting lard and animal fats due to their potential link to metabolic diseases. Nevertheless, emerging evidence suggests that lard may not significantly contribute to diabetes and that moderate lard intake could even benefit lipid metabolism. This commentary suggests a reevaluation of lard’s classification as a “bad actor” in the context of diabetes, urging colleagues to give greater consideration to and empirically validate this intriguing hypothesis.