Koontanatechanon Anantawat, Wongphatcharachai Manoosak, Nonthabenjawan Nutthawan, Jariyahatthakij Pichaya, Khorporn Thanchanok, Parnsen Wanpeuch, Keattisin Benjawan, Leksrisompong Pattarin, Srichana Pairat, Prasopdee Sattrachai, Roytrakul Sittiruk, Sriyakul Kusuma, Thitapakorn Veerachai, Pawa Kammal Kumar
Chulabhorn International College of Medicine, Thammasat University, Pathumthani, Thailand.
Feed Technology Office, Charoen Pokphand Foods Public Company Limited (CPF), Bangkok, Thailand.
Int J Food Sci. 2022 Nov 22;2022:9269968. doi: 10.1155/2022/9269968. eCollection 2022.
Hyperlipidemia is a risk factor for cardiovascular diseases. This study is aimed at investigating the effects of consuming omega-3-rich pork lard on the serum lipid profile and gut microbiome of the mice model.
We divided 23 C57BL/6NJ males (16-week-old) into 3 groups, and each group received either a control diet, a high-fat diet of coconut oil (coconut oil), or a high-fat diet of omega-3-rich pork lard (omega lard) for 28 days. Thereafter, fasting serum lipids and fecal microbiomes were analyzed. The serum cholesterol, triglyceride, and LDL levels of the omega lard-treated group were significantly reduced compared to the coconut oil-treated group ( < 0.05). However, the microbiome analysis revealed a significant increase in the abundance of in the omega lard-treated group compared to the coconut oil-treated group ( < 0.05). Furthermore, Spearman's correlation analysis revealed that the increased serum lipid content was positively correlated with the abundance of ( < 0.05) and negatively correlated with the abundance of ( < 0.05).
These findings suggested that omega-3-rich pork lard altered the serum lipid profile and gut microbiome in the mice model. . The excellent protection offered by omega-3-rich pork lard against hyperlipidemia indicated that pork lard could be used as alternative cooking oil for health-conscious individuals. It could also be introduced as a functional ingredient for patients with hyperlipidemia.
高脂血症是心血管疾病的一个危险因素。本研究旨在调查食用富含欧米伽-3的猪油对小鼠模型血清脂质谱和肠道微生物群的影响。
我们将23只16周龄的C57BL/6NJ雄性小鼠分为3组，每组分别给予对照饮食、椰子油高脂饮食（椰子油组）或富含欧米伽-3的猪油高脂饮食（欧米伽猪油组），持续28天。此后，分析空腹血清脂质和粪便微生物群。与椰子油处理组相比，欧米伽猪油处理组的血清胆固醇、甘油三酯和低密度脂蛋白水平显著降低（<0.05）。然而，微生物群分析显示，与椰子油处理组相比，欧米伽猪油处理组中某菌属的丰度显著增加（<0.05）。此外，Spearman相关性分析显示，血清脂质含量的增加与某菌属的丰度呈正相关（<0.05），与另一菌属的丰度呈负相关（<0.05）。
这些发现表明，富含欧米伽-3的猪油改变了小鼠模型的血清脂质谱和肠道微生物群。富含欧米伽-3的猪油对高脂血症具有出色的保护作用，这表明猪油可以作为注重健康者的替代食用油。它也可以作为高脂血症患者的功能性成分引入。 （注：原文中部分菌属名称未给出具体英文，用“某菌属”表示）
