Bai Tongtong, Wu Chengyu
Dongfang Hospital, Beijing University of Chinese Medicine, 100078, Beijing, China.
School of Chinese Medicine, Nanjing University of Chinese Medicine, No.138, Xianlin Avenue, Qixia District, Nanjing, 210023, Jiangsu, China.
Sci Rep. 2024 Dec 24;14(1):28465. doi: 10.1038/s41598-024-78787-4.
Extensive research is needed to examine the association between cardiovascular disease (CVD) and cancer. The observational study is based on data collected from the 2005-2018 National Health and Nutrition Examination Survey (NHANES). To assess the connection between CVDs and cancer, we used a weighted multivariable logistic regression analysis with as many confounding factors as feasible included in the model. By employing Mendelian randomization (MR), the unbiased causal relationship between CVDs and cancers was ascertained. The primary analytical approach employed the Inverse Variance Weighted methodology. In cross-sectional study, a positive correlation was observed between CVD and cancer (Model 3, Odds ratio 1.26, 95% confidence interval 1.01 ~ 1.57, p = 0.040). However, MR analysis indicated a negative causal relationship between certain subtypes of CVD and specific cancers, with effect sizes for coronary heart disease and lung cancer (β = - 4.759, p = 0.002), breast cancer (β = - 2.684, p = 0.026), colorectal cancer (β = - 4.581, p = 0.042), liver cancers (β = - 19.264, p = 0.028), and stroke with prostate cancer (β = - 0.299, p = 0.017), with no evidence of a positive correlation. Results from the reverse MR causal analysis revealed a positive correlation between prostate cancer and angina pectoris. An observational study linked CVDs risk to cancer risk. MR analysis has shown that the expected incidence of CVDs can reduce the probability of developing certain forms of cancer. Further investigation is required to examine the clinical correlations and underlying processes between these two illnesses.
需要进行广泛的研究来检验心血管疾病（CVD）与癌症之间的关联。该观察性研究基于从2005 - 2018年国家健康与营养检查调查（NHANES）收集的数据。为了评估心血管疾病与癌症之间的联系，我们使用了加权多变量逻辑回归分析，并在模型中纳入尽可能多的混杂因素。通过采用孟德尔随机化（MR）方法，确定了心血管疾病与癌症之间无偏的因果关系。主要的分析方法采用了逆方差加权法。在横断面研究中，观察到心血管疾病与癌症之间存在正相关（模型3，比值比1.26，95%置信区间1.01至1.57，p = 0.040）。然而，MR分析表明，某些心血管疾病亚型与特定癌症之间存在负因果关系，冠心病与肺癌（β = - 4.759，p = 0.002）、乳腺癌（β = - 2.684，p = 0.026）、结直肠癌（β = - 4.581，p = 0.042）、肝癌（β = - 19.264，p = 0.028）以及中风与前列腺癌（β = - 0.299，p = 0.017），均无正相关证据。反向MR因果分析结果显示前列腺癌与心绞痛之间存在正相关。一项观察性研究将心血管疾病风险与癌症风险联系起来。MR分析表明，心血管疾病的预期发病率可降低患某些形式癌症的概率。需要进一步研究以检验这两种疾病之间的临床相关性及潜在机制。
