Jiang Boyang, Chen Bingbing, Xu Jia, Luo Jieshu, Yao Min
FLOSSOM Shenzhen Research Institute, Shenzhen, China.
Shenzhen Rawskin Dermatology, Shenzhen, China.
J Cosmet Dermatol. 2025 Feb;24(2):e16749. doi: 10.1111/jocd.16749. Epub 2024 Dec 24.
Myoelectrical stimulation improves muscle function and reduces muscle atrophy and aging. However, research on the mechanism underlying its cosmetic effect remains limited.
The aim of this study was to evaluate the cosmetic effects of the myoelectrical stimulation provided by the wearable intelligent flexible beauty device and its focused electric field technology (FEFT) on facial skin and muscle rejuvenation.
PATIENTS/METHODS: We conducted a single-blind, randomized, self-controlled clinical efficacy experiment on 31 female volunteers using the device. Using an FEFT-based platform, mice with d-galactose-induced skeletal muscle aging were subjected to surface myoelectrical stimulation of the gastrocnemius. Immunohistochemical analysis of skeletal muscles and protein immunoblotting were used to analyze the effects of FEFT.
After 14 days of use, facial skin elasticity significantly increased, wrinkle firmness significantly decreased, and the lift height of the upper eyelid and eye corner angle significantly increased in the volunteers. Clinical evaluation showed improvements in the drooping of the upper eyelid and eye bags. Self-evaluation questionnaires indicated alleviation of facial wrinkles. These improvements were more pronounced after 28 days. In mice, FEFT alleviated aging-induced muscle fiber atrophy, muscle fiber cross-sectional area reduction, and muscle satellite cell loss. FEFT also increased the expression of myogenic factors, including myogenic differentiation 1 (MYOD1).
FEFT exerted a skin-tightening effect by initiating myogenic processes and increasing the transformation of muscle satellite cells. Our research promotes the development of FEFT-based medical rehabilitation or cosmetic anti-aging products and provides a foundation for further application and comprehensive efficacy evaluation in human clinical settings.
肌电刺激可改善肌肉功能，减少肌肉萎缩和衰老。然而，关于其美容效果潜在机制的研究仍然有限。
本研究旨在评估可穿戴智能柔性美容设备及其聚焦电场技术（FEFT）提供的肌电刺激对面部皮肤和肌肉年轻化的美容效果。
患者/方法：我们使用该设备对31名女性志愿者进行了单盲、随机、自身对照的临床疗效实验。利用基于FEFT的平台，对d-半乳糖诱导的骨骼肌衰老小鼠的腓肠肌进行表面肌电刺激。采用骨骼肌免疫组织化学分析和蛋白质免疫印迹法分析FEFT的作用效果。
使用14天后，志愿者的面部皮肤弹性显著增加，皱纹紧致度显著降低，上眼睑和眼角角度的提升高度显著增加。临床评估显示上眼睑下垂和眼袋有所改善。自我评估问卷表明面部皱纹有所减轻。28天后这些改善更为明显。在小鼠中，FEFT减轻了衰老诱导的肌纤维萎缩、肌纤维横截面积减小和肌肉卫星细胞丢失。FEFT还增加了包括生肌分化1（MYOD1）在内的生肌因子的表达。
FEFT通过启动生肌过程和增加肌肉卫星细胞的转化发挥紧致皮肤的作用。我们的研究促进了基于FEFT的医学康复或美容抗衰产品的开发，并为其在人体临床环境中的进一步应用和综合疗效评估提供了基础。
