Liang Katharine J, Colasurdo Elizabeth A, Li Ge, Shofer Jane B, Galasko Douglas, Quinn Joseph F, Farlow Martin R, Peskind Elaine R
VA Northwest Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA.
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA 98195, USA.
J Endocr Soc. 2024 Dec 5;9(1):bvae220. doi: 10.1210/jendso/bvae220. eCollection 2024 Nov 26.
Many studies have moved toward saliva and peripheral blood sampling for studying cortisol, even in relation to disorders of the brain. However, the degree to which peripheral cortisol reflects central cortisol levels has yet to be comprehensively described. Data describing the effect that biological characteristics such as age and sex have on cortisol levels across compartments is also limited.
To assess the relationships of cortisol levels across cerebrospinal fluid (CSF), saliva, and plasma (total and free) compartments and describe the effects of age and sex on these relationships.
Multisite cross-sectional observation study.
Samples collected in academic outpatient settings in 2001-2004.
Healthy community volunteers (n = 157) of both sexes, aged 20-85 years.
None.
This study was a secondary analysis of data collected from a previously published study.
CSF cortisol correlated more strongly with plasma (r = 0.49, < .0001) than with saliva cortisol levels. Sex but not age was a significant modifier of these relationships. CSF cortisol levels trended higher with older age in men (R = 0.31, < .001) but not women. Age-related cortisol binding globulin trends differed by sex but did not correlate with sex differences in cortisol levels in any compartment.
Variability in the correlations between central and peripheral cortisol discourages the use of peripheral cortisol as a direct surrogate for central cortisol measures. Further investigation of how mechanistic drivers interact with biological factors such as sex will be necessary to fully understand the dynamics of cortisol regulation across fluid compartments.
许多研究已转向通过唾液和外周血采样来研究皮质醇，甚至是与脑部疾病相关的研究。然而，外周皮质醇反映中枢皮质醇水平的程度尚未得到全面描述。关于年龄和性别等生物学特征对不同部位皮质醇水平影响的数据也很有限。
评估脑脊液（CSF）、唾液和血浆（总皮质醇和游离皮质醇）中皮质醇水平之间的关系，并描述年龄和性别对这些关系的影响。
多中心横断面观察研究。
2001年至2004年在学术门诊收集的样本。
年龄在20 - 85岁之间的健康社区志愿者（n = 157），男女均有。
无。
本研究是对先前发表研究中收集的数据进行的二次分析。
脑脊液皮质醇与血浆皮质醇的相关性更强（r = 0.49，P <.0001），而与唾液皮质醇水平的相关性较弱。性别而非年龄是这些关系的显著调节因素。男性脑脊液皮质醇水平随年龄增长呈上升趋势（R = 0.31，P <.001），而女性则不然。年龄相关的皮质醇结合球蛋白趋势因性别而异，但与任何部位皮质醇水平的性别差异均无相关性。
中枢和外周皮质醇之间相关性的变异性不支持将外周皮质醇直接作为中枢皮质醇测量的替代指标。要全面了解不同体液中皮质醇调节的动态变化，有必要进一步研究机制驱动因素如何与性别等生物学因素相互作用。
