a School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON K1N 1A2, Canada.
b Department of Biochemistry Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Appl Physiol Nutr Metab. 2018 May;43(5):445-452. doi: 10.1139/apnm-2017-0551. Epub 2017 Dec 4.
This study assessed blood levels of cortisol and cytokines (inflammatory and non-inflammatory) in members of the regular Canadian Armed Forces (CAF), and examined the associations between sex, age, and adiposity and circulating levels of cortisol as well as pro- and anti-inflammatory cytokines. As part of a larger ranging project, 331 blood samples were collected from a representative population of the total CAF, which included officers and noncommissioned women and men from the Air Force, Navy, and Army. The blood samples were analyzed for levels of cortisol, C-reactive protein (CRP), adiponectin, and 20 cytokines (which included interleukins, interferons, and tumor necrosis factors). Higher levels of adiponectin were found in women compared with men (median and interquartile range; 16.71 (7.68-25.32) vs 5.81 (3.52-13.19) μg/mL), and higher levels of interleukin (IL)-18 in men compared with women (89.25 (84.03-94.48) vs 75.91 (69.70-82.13) pg/mL). An association between age and levels of stress and inflammatory cytokines was observed, with CRP, IL-18, IL-2 and adiponectin all increasing with increasing age. However, contrary to trends seen in the general population, cortisol levels decreased with increasing age. Levels of CRP and IL-18 increased with an increase in adiposity, while adiponectin levels decreased. Most importantly, at the entire cohort level, a low detection rate for most of the cytokines was observed with 17 out of 22 cytokines having a detection below 10%.
In this CAF population, although an association between age and inflammatory cytokines was observed, both sex and adiposity had a small impact on levels of cortisol and cytokines.
本研究评估了加拿大正规军（CAF）成员的皮质醇和细胞因子（炎症性和非炎症性）的血液水平，并研究了性别、年龄和肥胖与循环皮质醇以及促炎和抗炎细胞因子水平之间的关联。作为一个更大范围项目的一部分，从 CAF 的总代表性人群中采集了 331 份血液样本，其中包括空军、海军和陆军的军官和男女非委任人员。分析了这些血液样本中的皮质醇、C 反应蛋白（CRP）、脂联素和 20 种细胞因子（包括白细胞介素、干扰素和肿瘤坏死因子）的水平。与男性相比，女性的脂联素水平更高（中位数和四分位距；16.71（7.68-25.32）与 5.81（3.52-13.19）μg/ml），男性的白细胞介素（IL）-18 水平也更高与女性（89.25（84.03-94.48）与 75.91（69.70-82.13）pg/ml）。观察到年龄与应激和炎症细胞因子水平之间存在关联，随着 CRP、IL-18、IL-2 和脂联素的增加，年龄也在增加。然而，与一般人群的趋势相反，皮质醇水平随着年龄的增长而降低。CRP 和 IL-18 水平随着肥胖程度的增加而增加，而脂联素水平则降低。最重要的是，在整个队列水平上，观察到大多数细胞因子的检出率很低，22 种细胞因子中有 17 种的检出率低于 10%。
在 CAF 人群中，尽管观察到年龄与炎症性细胞因子之间存在关联，但性别和肥胖对皮质醇和细胞因子水平的影响很小。
