Morsiani E, Carpanelli M C
Eur Surg Res. 1985;17(1):25-32. doi: 10.1159/000128443.
A 50% small bowel bypass was performed in diabetic rats (streptozotocin-treated) and in normal rats. Normal rats and diabetic rats were used as controls. Values of fasting blood glucose and oral glucose tolerance test showed a normalization and the disappearance of glycosuria, polyuria, polydipsia and hyperphagia in diabetic rats after surgery. Mean loss of weight 3 months after surgery was 9.1% in normal bypassed rats and 60.5% in the diabetic controls. After an initial postoperative weight loss of 33.4%, the diabetic bypassed rats gained subsequently their previous weight plus an increase of 7.2%. Improvement in carbohydrate metabolism appears to be independent of loss of weight and decrease in food intake in lean diabetic rats. Amelioration of diabetes after jejunoileal bypass is the result of several metabolic consequences, particularly the malabsorption of carbohydrates, fats and amino acids.
对糖尿病大鼠（经链脲佐菌素处理）和正常大鼠进行了50%的小肠旁路手术。正常大鼠和糖尿病大鼠作为对照。空腹血糖值和口服葡萄糖耐量试验显示，术后糖尿病大鼠的血糖恢复正常，糖尿、多尿、烦渴和多食症状消失。术后3个月，正常旁路大鼠的平均体重减轻9.1%，糖尿病对照大鼠的平均体重减轻60.5%。糖尿病旁路大鼠术后最初体重减轻33.4%，随后体重恢复到术前水平，并增加了7.2%。在瘦型糖尿病大鼠中，碳水化合物代谢的改善似乎与体重减轻和食物摄入量减少无关。空肠回肠旁路术后糖尿病症状的改善是多种代谢后果的结果，尤其是碳水化合物、脂肪和氨基酸的吸收不良。
