Ahmad U, Danowski T S, Nolan S, Stephan T, Sunder J H, Bahl V K
Diabetes Care. 1978 May-Jun;1(3):158-65. doi: 10.2337/diacare.1.3.158.
Limited weight loss following jejunoileal bypass in 24 diabetic persons who were still distinctly overweight five to ten months after a mean weight decrease of 78 lbs. was accompanied by a return of normal fasting glucose and insulin levels, normal insulin responses, and a decrease in glucose intolerance. The glucose disappearance rate had improved in the majority of the subjects, but only three had attained values in the normal range. Concomitants of the undue hyperglycemia and/or obesity included labile and, rarely, sustained hypertension and/or cardiomegaly. The blood pressure returned to normal but heart size did not change. Electrocardiographic abnormalities noted in about one-half of the patients persisted after the operation. Triglyceride and cholesterol levels decreased. No patients had diabetic retinopathy visible on funduscopy. Proteinuria did not change in three patients. Neuropathy consisting of absent ankle reflexes and/or decreased vibration perception noted in one-half of the subjects persisted despite the improvement in carbohydrate metabolism.
24名糖尿病患者接受空肠回肠分流术后体重减轻有限，在平均体重下降78磅后的五到十个月仍明显超重，同时空腹血糖和胰岛素水平恢复正常，胰岛素反应正常，葡萄糖耐量降低。大多数受试者的葡萄糖消失率有所改善，但只有三人达到正常范围值。过度高血糖和/或肥胖的伴随症状包括不稳定且很少持续的高血压和/或心脏扩大。血压恢复正常，但心脏大小未改变。约一半患者术后心电图异常持续存在。甘油三酯和胆固醇水平降低。眼底镜检查未发现患者有糖尿病视网膜病变。三名患者的蛋白尿没有变化。尽管碳水化合物代谢有所改善，但一半受试者中出现的由踝反射消失和/或振动觉减退组成的神经病变仍然存在。
