Um Ji Young, Choi Min Gyu, Kim Han Bi, Lee So Yeon, Park Gi Hyun, Kim Hea Won, Chung Bo Young, Park Chun Wook, Kim Hye One
Department of Dermatology, College of Medicine, Hallym University, Kangnam Sacred Heart Hospital, Seoul, Korea.
Department of Computer Science, Kwangwoon University, Seoul, Korea.
Clin Cosmet Investig Dermatol. 2024 Dec 19;17:2945-2952. doi: 10.2147/CCID.S486770. eCollection 2024.
Sensitive skin causes discomfort from irritants, impacting quality of life. While hypoallergenic moisturizers help prevent moisture loss, some ingredients can still cause irritation. Treatments like steroids and calcineurin inhibitors have side effects, and chemical sunscreens can cause irritation in sensitive skin.
In this study, we performed a patch test by applying Bariderm Shield Cream MD in patients with facial dermatitis or sensitive skin with weakened skin barrier function and investigated whether it had an effect in relieving clinical symptoms and improving skin barrier function. We also want to find out the safety of whether new dermatitis will not occur.
15 pruritus patients (average age 33.07 ± 11.57) applied this twice daily for 8 weeks. Effectiveness was evaluated using SS-10 (Sensitive scale-10), severity by area, TEWL (transepidermal water loss), and SCH (skin corneum hydration). We performed repeated measures ANOVA and post hoc analysis using Python statistics.
Fifteen pruritus patients (average age 33.07 ± 11.57) applied this twice daily for 8 weeks. Effectiveness was evaluated using SS-10 (Sensitive scale-10), severity by area, TEWL (transepidermal water loss), and SCH (skin corneum hydration). SS-10 showed a significant difference at week 8. TEWL decreased after 8 weeks, while moisture increased after 4 weeks of application. Severity scores for erythema, scales, papules, and pustules on both cheeks notably decreased compared to baseline at week 4 and 8 after application.
This study shows that Barriederm Shield Cream MD® is safe for patients with sensitive skin. It suggests that it is suitable for sensitive skin, with the result of improving the skin barrier, and addresses safety and efficacy issues.
敏感性皮肤会因刺激物而产生不适，影响生活质量。虽然低敏保湿霜有助于防止水分流失，但某些成分仍可能引起刺激。类固醇和钙调神经磷酸酶抑制剂等治疗方法有副作用，化学防晒霜会引起敏感性皮肤的刺激。
在本研究中，我们对患有面部皮炎或皮肤屏障功能减弱的敏感性皮肤患者涂抹巴瑞 Derm 护盾霜 MD 进行斑贴试验，研究其是否对缓解临床症状和改善皮肤屏障功能有作用。我们还想了解使用后是否不会出现新发皮炎的安全性情况。
15 名瘙痒患者（平均年龄 33.07 ± 11.57）每天涂抹两次，持续 8 周。使用 SS - 10（敏感性量表 - 10）评估有效性，通过面积评估严重程度，测量经表皮水分流失（TEWL）和角质层水合作用（SCH）。我们使用 Python 统计学方法进行重复测量方差分析和事后分析。
15 名瘙痒患者（平均年龄 33.07 ± 11.57）每天涂抹两次，持续 8 周。使用 SS - 10（敏感性量表 - 10）评估有效性，通过面积评估严重程度，测量经表皮水分流失（TEWL）和角质层水合作用（SCH）。第 8 周时 SS - 10 显示出显著差异。8 周后 TEWL 降低，涂抹 4 周后水分增加。与基线相比，涂抹后第 4 周和第 8 周时双颊红斑、鳞屑、丘疹和脓疱 的严重程度评分显著降低。
本研究表明，巴瑞 Derm 护盾霜 MD® 对敏感性皮肤患者是安全的。这表明它适用于敏感性皮肤，具有改善皮肤屏障的效果，并解决了安全性和有效性问题。
