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神经影像学中的协同作用：PET-CT与MRI融合用于增强脑病理学特征分析

Synergy in Neuroimaging: PET-CT and MRI Fusion for Enhanced Characterization of Brain Pathology.

作者信息

Radder Nivedita, Sonar Sameer, Nanivadekar Avinash, Radder Shrinivas

机构信息

Diagnostic Radiology, University of Arkansas for Medical Sciences, Little Rock, USA.

Nuclear Medicine/PET-CT, Ruby Hall Clinic, Pune, IND.

出版信息

Cureus. 2024 Nov 24;16(11):e74353. doi: 10.7759/cureus.74353. eCollection 2024 Nov.

DOI:10.7759/cureus.74353
PMID:39720378
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11668271/
Abstract

BACKGROUND

Accurate diagnosis and understanding of brain disorders are crucial for the best treatment. While multimodal neuroimaging is essential, it has its limitations. Conventional computed tomography (CT) and magnetic resonance imaging (MRI) provide detailed anatomical information but lack molecular insights, while 18F-fluorodeoxyglucose-positron emission tomography (FDG PET) offers metabolic data but often has limited spatial resolution.

OBJECTIVE

This study aimed to assess the potential of combining 18F-FDG PET with MRI to characterize brain disorders compared to standard imaging methods.

METHODS

Fifty patients suspected of having brain tumors underwent 18F-FDG PET-CT and then MRI (including 3D fluid-attenuated inversion recovery (FLAIR)) after CT scans revealed suspicious lesions. The images were combined and PET-MRI findings were compared to the initial CT interpretations.

RESULTS

The combination of PET-MRI significantly improved diagnostic accuracy in 20 out of the 50 patients (40%). Importantly, it identified and characterized brain lesions missed by CT in two patients (4%). In patients with known dementia or epilepsy, PET-MRI revealed specific metabolic patterns in affected brain areas.

CONCLUSION

18F-FDG PET-MRI fusion shows greater sensitivity and specificity than standard imaging techniques for various brain disorders. It provides valuable insights into structural and functional abnormalities, potentially leading to improved diagnosis, treatment planning, and patient outcomes.

摘要

背景

准确诊断和了解脑部疾病对于最佳治疗至关重要。虽然多模态神经影像学至关重要，但它也有其局限性。传统计算机断层扫描（CT）和磁共振成像（MRI）提供详细的解剖信息，但缺乏分子层面的见解，而18F-氟脱氧葡萄糖正电子发射断层扫描（FDG PET）提供代谢数据，但空间分辨率往往有限。

目的

本研究旨在评估与标准成像方法相比，将18F-FDG PET与MRI相结合来表征脑部疾病的潜力。

方法

50名疑似患有脑肿瘤的患者在CT扫描发现可疑病变后接受了18F-FDG PET-CT检查，然后进行MRI检查（包括三维液体衰减反转恢复序列（FLAIR））。将图像进行合并，并将PET-MRI结果与最初的CT解读进行比较。

结果

PET-MRI联合检查显著提高了50名患者中20名患者（40%）的诊断准确性。重要的是，它发现并表征了两名患者（4%）中CT遗漏的脑部病变。在已知患有痴呆症或癫痫的患者中，PET-MRI显示了受影响脑区的特定代谢模式。

结论

18F-FDG PET-MRI融合对各种脑部疾病的敏感性和特异性高于标准成像技术。它为结构和功能异常提供了有价值的见解，可能有助于改善诊断、治疗计划和患者预后。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/89acc4af774a/cureus-0016-00000074353-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/f9bc34bff6c7/cureus-0016-00000074353-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/e1f548ba901c/cureus-0016-00000074353-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/6e11a3fe2466/cureus-0016-00000074353-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/dfef3841c01f/cureus-0016-00000074353-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/0930a733a70e/cureus-0016-00000074353-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/db29a981cab3/cureus-0016-00000074353-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/b880cf597ec5/cureus-0016-00000074353-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/5928676cdec6/cureus-0016-00000074353-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/edd0cadbf000/cureus-0016-00000074353-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/89acc4af774a/cureus-0016-00000074353-i10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/f9bc34bff6c7/cureus-0016-00000074353-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/e1f548ba901c/cureus-0016-00000074353-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/6e11a3fe2466/cureus-0016-00000074353-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/dfef3841c01f/cureus-0016-00000074353-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/0930a733a70e/cureus-0016-00000074353-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/db29a981cab3/cureus-0016-00000074353-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/b880cf597ec5/cureus-0016-00000074353-i07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/5928676cdec6/cureus-0016-00000074353-i08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/edd0cadbf000/cureus-0016-00000074353-i09.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c161/11668271/89acc4af774a/cureus-0016-00000074353-i10.jpg

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