Cherukuri Lavanya, Birudaraju Divya, Budoff Matthew J
The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Torrance, CA.
Division of Cardiology, Harbor-UCLA Medical Center Torrance, CA.
US Cardiol. 2021 Apr 23;15:e06. doi: 10.15420/usc.2020.24. eCollection 2021.
Coronary artery disease (CAD) patients may have an obstructive disease on invasive coronary angiography, but few of these patients have had flow-limiting obstructive disease diagnosed on invasive fractional flow reserve (FFR). FFR is infrequently performed because of its cost- and time-effectiveness. Advancement in non-invasive imaging has enabled FFR to be derived non-invasively using coronary CT angiography (CCTA), without the need for induction of hyperemia or modification of the standard CCTA acquisition protocol. FFR derived from CCTA (FFR) has been shown to have excellent correlation with invasive FFR, and remains an effective diagnostic tool in the presence of reduced signal-to-noise ratio, coronary calcification and motion artifact. The utility of FFR has also helped to deepen our understanding of hemodynamically significant CAD. Hence, there is now interest in exploring the possible interplay between these mechanistic forces and their effect on the development of coronary plaque and the vulnerability of these plaques.
冠状动脉疾病（CAD）患者在有创冠状动脉造影检查中可能存在阻塞性病变，但这些患者中很少有人在有创血流储备分数（FFR）检查中被诊断为存在血流限制性阻塞性病变。由于其成本效益和时间效益，FFR检查并不常用。无创成像技术的进步使得可以通过冠状动脉CT血管造影（CCTA）无创地得出FFR，而无需诱发充血或修改标准的CCTA采集方案。经CCTA得出的FFR（FFRCT）已被证明与有创FFR具有极好的相关性，并且在存在信噪比降低、冠状动脉钙化和运动伪影的情况下仍然是一种有效的诊断工具。FFRCT的实用性也有助于加深我们对具有血流动力学意义的CAD的理解。因此，现在人们有兴趣探索这些机制性力量之间可能的相互作用及其对冠状动脉斑块形成和这些斑块易损性的影响。
