Lam Jonathan, Hussain Rumana, Coupland Sarah E, Heimann Heinrich
St Pauls Eye Clinic, Liverpool University Hospitals NHS Foundation Trust, Liverpool, United Kingdom.
Liverpool Ocular Oncology Research Group, Department of Eye and Vision Science, University of Liverpool, Liverpool, United Kingdom.
Front Med (Lausanne). 2024 Dec 9;11:1483788. doi: 10.3389/fmed.2024.1483788. eCollection 2024.
We report a rare case of a rapidly growing and large conjunctival histoplasmosis lesion in an immunosuppressed West African woman in her 80s, affecting her only eye. The patient had undergone a renal transplant and was on immunosuppressive medications. Additionally, she had previously been treated for presumed systemic histoplasmosis with itraconazole more than 5 years ago. Despite receiving previous treatment, she presented with a large conjunctival lesion, which was confirmed to be histoplasmosis after an excisional biopsy. The lesion was observed to grow over a 2-week period, causing significant visual impairment. Following a comprehensive systems review and investigation, the conjunctiva was identified as the sole site of infection. This case underscores the rarity of sight-threatening Histoplasma infections in the conjunctiva of an immunosuppressed individual. Conjunctival histoplasmosis lesions are rarely reported, with even fewer cases documented as primarily originating from this location.
我们报告了一例罕见病例，一名80多岁的西非免疫抑制女性单眼出现迅速生长的巨大结膜组织胞浆菌病病变。该患者接受了肾移植，正在服用免疫抑制药物。此外，她在5年多以前曾因疑似系统性组织胞浆菌病接受伊曲康唑治疗。尽管之前接受过治疗，但她仍出现了一个巨大的结膜病变，切除活检后确诊为组织胞浆菌病。观察到病变在2周内生长，导致严重视力损害。经过全面的系统检查和调查，发现结膜是唯一的感染部位。该病例凸显了免疫抑制个体结膜发生威胁视力的组织胞浆菌感染的罕见性。结膜组织胞浆菌病病变鲜有报道，主要起源于该部位的病例更是少之又少。
