长链非编码RNA EGFR-AS1通过调控miR-449a/HDAC1促进肺癌细胞的增殖、侵袭和转移。
LncRNA EGFR‑AS1 promotes lung cancer cell proliferation, invasion and metastasis via regulation of miR‑449a/HDAC1.
作者信息
Huang Jie, Wang Baoqing, Wu Qin, Wang Liming, Guan Chao
机构信息
Department of Respiratory Medicine, Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Fudan University, Xuhui, Shanghai 200031, P.R. China.
Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Xuhui, Shanghai 200031, P.R. China.
出版信息
Exp Ther Med. 2024 Dec 3;29(2):27. doi: 10.3892/etm.2024.12777. eCollection 2025 Feb.
There is increasing evidence that long non-coding (lnc)RNA EGFR-AS1 is involved in the development of numerous types of cancer, including non-small-cell lung cancer (NSCLC). The Cancer Genome Atlas (TCGA) demonstrates that EGFR-AS1 is highly expressed in NSCLC. Downregulation of EGFR-AS1 in A549 and PC9 NSCLC cells demonstrates inhibition of NSCLC proliferation, invasion and metastasis. The present study demonstrated that lncRNA EGFR-AS1 was essential for the development of NSCLC through its function as a competitive endogenous RNA binding to miR-449a and upregulating histone deacetylase 1. In brief, it identified a novel signaling pathway that mediated the invasion and metastasis of NSCLC and may therefore provide a new treatment target for NSCLC.
越来越多的证据表明，长链非编码（lnc）RNA EGFR-AS1参与了包括非小细胞肺癌（NSCLC）在内的多种癌症的发展。癌症基因组图谱（TCGA）显示，EGFR-AS1在NSCLC中高表达。在A549和PC9 NSCLC细胞中下调EGFR-AS1可抑制NSCLC的增殖、侵袭和转移。本研究表明，lncRNA EGFR-AS1通过作为竞争性内源性RNA与miR-449a结合并上调组蛋白去乙酰化酶1，对NSCLC的发展至关重要。简而言之，它确定了一条介导NSCLC侵袭和转移的新信号通路，因此可能为NSCLC提供新的治疗靶点。
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