Novel rearrangement of purines.
作者信息
Barak A, Agranat I
出版信息
Experientia. 1985 Feb 15;41(2):248-51. doi: 10.1007/BF02002620.
PMID:3972070
Abstract
6-Trichloromethyl-9-methylpurine (1) rearranges to 6-dichloromethyl-9-methyl-8-oxopurine (2) in aqueous mild acidic solution. The rearrangement is rationalized in terms of a reaction involving protonation, covalent hydration, prototropic equilibrium and/or a hydride transfer. An alternative mechanism involving a "positive' halogen compound and hypochlorous acid as an intermediary is also proposed. Compound 1 condenses with 4,5-diaminopyrimidine to give the purine-pyrimidine Schiff base pair 4.
摘要
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