Downey John E, Schone Hunter R, Foldes Stephen T, Greenspon Charles, Liu Fang, Verbaarschot Ceci, Biro Daniel, Satzer David, Moon Chan Hong, Coffman Brian A, Youssofzadeh Vahab, Fields Daryl, Hobbs Taylor G, Okorokova Elizaveta, Tyler-Kabara Elizabeth C, Warnke Peter C, Gonzalez-Martinez Jorge, Hatsopoulos Nicholas G, Bensmaia Sliman J, Boninger Michael L, Gaunt Robert A, Collinger Jennifer L
Department of Organismal Biology and Anatomy, University of Chicago, Chicago, Illinois, USA.
Rehab Neural Engineering Labs, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Hum Brain Mapp. 2024 Dec 15;45(18):e70118. doi: 10.1002/hbm.70118.
Intracortical microstimulation (ICMS) is a method for restoring sensation to people with paralysis as part of a bidirectional brain-computer interface (BCI) to restore upper limb function. Evoking tactile sensations of the hand through ICMS requires precise targeting of implanted electrodes. Here we describe the presurgical imaging procedures used to generate functional maps of the hand area of the somatosensory cortex and subsequent planning that guided the implantation of intracortical microelectrode arrays. In five participants with cervical spinal cord injury, across two study locations, this procedure successfully enabled ICMS-evoked sensations localized to at least the first four digits of the hand. The imaging and planning procedures developed through this clinical trial provide a roadmap for other BCI studies to ensure the successful placement of stimulation electrodes.
皮层内微刺激（ICMS）是一种作为双向脑机接口（BCI）的一部分，用于恢复瘫痪患者感觉以恢复上肢功能的方法。通过ICMS唤起手部的触觉需要精确靶向植入电极。在这里，我们描述了用于生成体感皮层手部区域功能图谱的术前成像程序以及指导皮层内微电极阵列植入的后续规划。在两个研究地点的五名颈脊髓损伤参与者中，该程序成功实现了ICMS诱发的感觉至少定位到手部的前四指。通过该临床试验开发的成像和规划程序为其他BCI研究提供了路线图，以确保刺激电极的成功放置。
