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通过体感皮层的多电极皮层内微刺激唤起稳定且精确的触觉感受。

Evoking stable and precise tactile sensations via multi-electrode intracortical microstimulation of the somatosensory cortex.

作者信息

Greenspon Charles M, Valle Giacomo, Shelchkova Natalya D, Hobbs Taylor G, Verbaarschot Ceci, Callier Thierri, Berger-Wolf Ev I, Okorokova Elizaveta V, Hutchison Brianna C, Dogruoz Efe, Sobinov Anton R, Jordan Patrick M, Weiss Jeffrey M, Fitzgerald Emily E, Prasad Dillan, Van Driesche Ashley, He Qinpu, Liu Fang, Kirsch Robert F, Miller Jonathan P, Lee Ray C, Satzer David, Gonzalez-Martinez Jorge, Warnke Peter C, Ajiboye Abidemi B, Graczyk Emily L, Boninger Michael L, Collinger Jennifer L, Downey John E, Miller Lee E, Hatsopoulos Nicholas G, Gaunt Robert A, Bensmaia Sliman J

机构信息

Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL, USA.

Committee on Computational Neuroscience, University of Chicago, Chicago, IL, USA.

出版信息

Nat Biomed Eng. 2024 Dec 6. doi: 10.1038/s41551-024-01299-z.

Abstract

Tactile feedback from brain-controlled bionic hands can be partially restored via intracortical microstimulation (ICMS) of the primary somatosensory cortex. In ICMS, the location of percepts depends on the electrode's location and the percept intensity depends on the stimulation frequency and amplitude. Sensors on a bionic hand can thus be linked to somatotopically appropriate electrodes, and the contact force of each sensor can be used to determine the amplitude of a stimulus. Here we report a systematic investigation of the localization and intensity of ICMS-evoked percepts in three participants with cervical spinal cord injury. A retrospective analysis of projected fields showed that they were typically composed of a focal hotspot with diffuse borders, arrayed somatotopically in keeping with their underlying receptive fields and stable throughout the duration of the study. When testing the participants' ability to rapidly localize a single ICMS presentation, individual electrodes typically evoked only weak sensations, making object localization and discrimination difficult. However, overlapping projected fields from multiple electrodes produced more localizable and intense sensations and allowed for a more precise use of a bionic hand.

摘要

通过对初级体感皮层进行皮层内微刺激(ICMS),可部分恢复脑控仿生手的触觉反馈。在ICMS中,感觉的位置取决于电极的位置,感觉强度取决于刺激频率和幅度。因此,仿生手上的传感器可与躯体定位合适的电极相连,每个传感器的接触力可用于确定刺激的幅度。在此,我们报告了对三名颈脊髓损伤患者ICMS诱发感觉的定位和强度进行的系统研究。对投射区域的回顾性分析表明,它们通常由边界模糊的局灶性热点组成,按躯体定位排列,与其潜在的感受野一致,且在研究期间保持稳定。在测试参与者快速定位单个ICMS刺激的能力时,单个电极通常仅诱发微弱的感觉,使得物体定位和辨别变得困难。然而,多个电极重叠的投射区域产生了更易于定位且更强烈的感觉,从而使仿生手的使用更加精确。

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