Mimnaugh E G, Siddik Z H, Trush M A, Drew R, Gram T E
Drug Metab Dispos. 1979 Jul-Aug;7(4):208-10.
The effect of unilateral pneumonectomy on the drug-metabolizing capability of the remaining lung of male rabbits was studied 3, 10, and 28 days after surgery. During the period of compensatory lung growth which follows pneumonectomy, the contralateral lung had a reduced ability to metabolize some model drug substrates. The activities of 4-chloro-N-methylaniline demethylase, glutathione transferase, and 4-aminobenzoate N-acetyltransferase were significantly decreased in pneumonectomizd animals relative to shamoperated controls at 10 days. By 28 days most of these parameters of drug metabolism had returned to control levels. Lung hydroxyproline concentration, an index of collagen, did not differ in pneumonectomized and control animals at any of the time points. 3-Methylcholanthrene failed to induce the pulmonary mono-oxygenase system in pneumonectomized animals. The response of pulmonary drug-metabolizing enzymes to unilateral pneumonectomy in rabbits was temporally and qualitatively similar to the response in rat liver following partial hepatectomy.
研究了单侧肺切除术后3天、10天和28天对雄性兔剩余肺脏药物代谢能力的影响。在肺切除术后的代偿性肺生长期间，对侧肺代谢某些模型药物底物的能力降低。与假手术对照组相比，肺切除动物在10天时4-氯-N-甲基苯胺脱甲基酶、谷胱甘肽转移酶和4-氨基苯甲酸N-乙酰转移酶的活性显著降低。到28天时，这些药物代谢参数大多已恢复到对照水平。肺羟脯氨酸浓度作为胶原蛋白的指标，在任何时间点肺切除动物和对照动物之间均无差异。3-甲基胆蒽未能诱导肺切除动物的肺单加氧酶系统。兔肺药物代谢酶对单侧肺切除的反应在时间和性质上与大鼠部分肝切除后肝脏的反应相似。
