Maruani Julia, Vissouze Lily, Hebert Marc, Rach Heloise, Zehani Feriel, Lejoyeux Michel, Bourgin Patrice, Geoffroy Pierre A
Département de psychiatrie et d'addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Bichat - Claude Bernard, F-75018 Paris, France; Université Paris Cité, NeuroDiderot, Inserm, FHU I2-D2, F-75019 Paris, France; Centre ChronoS, GHU Paris - Psychiatrie & Neurosciences, 1 rue Cabanis, 75014 Paris, France.
Département de psychiatrie et d'addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hôpital Bichat - Claude Bernard, F-75018 Paris, France; Université Paris Cité, NeuroDiderot, Inserm, FHU I2-D2, F-75019 Paris, France; Centre ChronoS, GHU Paris - Psychiatrie & Neurosciences, 1 rue Cabanis, 75014 Paris, France.
Psychiatry Res. 2025 Feb;344:116333. doi: 10.1016/j.psychres.2024.116333. Epub 2024 Dec 19.
Depressive disorders are characterized by disturbances in light signal processing. More specifically, an alteration of the melanopsin response is suggested. The post-illumination pupillary response (PIPR) to blue light (post-blue PIPR) is increasingly used as a marker of the activity of intrinsically photosensitive melanopsin ganglion cells (ipRGCs). We hypothesized that individuals with Major Depressive Episode (MDE) who exhibited a higher vulnerability to season patterns showed a decreased ability to transmit light signals to the brain. We explored the correlation between the post-blue PIPR and the Global Seasonality Score (GSS) in 21 patients with MDE. The GSS was assessed using the Seasonal Pattern Assessment Questionnaire (SPAQ). The results revealed that decreased relative and absolute post-blue PIPR, suggesting a melanopsinergic hyposensitivity, were associated independently and significantly with higher seasonality in the psychological factor including a greater seasonal variation in sleep duration, mood, energy level and social activity, but were not associated with higher seasonality in the dietary factor (including weight and appetite seasonal variations) or with the severity of anxiety, depression, or sleep disturbances. Interestingly, mediation analyses highlight independent bidirectional effects of high vulnerability to season of psychological factors and decreased ipRGC sensitivity. Post-blue PIPR could be an objective marker of seasonal changes in daylight exposure in patients with MDE. Further research could explore post-blue PIPR as a state or trait biomarker for depressive disorders and the seasonal pattern, and its potential role in predicting therapeutic response to light therapy.
抑郁症的特征是光信号处理紊乱。更具体地说，提示黑视蛋白反应存在改变。对蓝光的光照后瞳孔反应（PIPR）（蓝光后PIPR）越来越多地被用作内在光敏性黑视蛋白神经节细胞（ipRGCs）活性的标志物。我们假设，对季节模式表现出较高易感性的重度抑郁发作（MDE）个体向大脑传递光信号的能力下降。我们在21例MDE患者中探讨了蓝光后PIPR与全球季节性评分（GSS）之间的相关性。使用季节性模式评估问卷（SPAQ）对GSS进行评估。结果显示，蓝光后PIPR的相对值和绝对值降低，提示黑视蛋白能低敏反应，与心理因素中较高的季节性独立且显著相关，包括睡眠时间、情绪、能量水平和社交活动的更大季节性变化，但与饮食因素中的较高季节性（包括体重和食欲的季节性变化）或焦虑、抑郁或睡眠障碍的严重程度无关。有趣的是，中介分析突出了心理因素对季节的高易感性和ipRGC敏感性降低的独立双向效应。蓝光后PIPR可能是MDE患者日光暴露季节性变化的客观标志物。进一步的研究可以探索蓝光后PIPR作为抑郁症和季节性模式的一种状态或特质生物标志物，以及它在预测光疗治疗反应中的潜在作用。
