Wan Yujie, Ding Jiali, Fan Mengmeng, Huang Hailiang
College of Rehabilitation Medicine, Shangdong University of Traditional Chinese Medicine, Jinan City, Shangdong Province, China.
High Level Key Disciplines of Traditional Chinese Medicine Basic Theory of Traditional Chinese Medicine, National Administration of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, PR China.
Medicine (Baltimore). 2025 Jul 4;104(27):e43107. doi: 10.1097/MD.0000000000043107.
To determine the efficacy of different visible light therapies in treating seasonal affective disorder (SAD) through both direct and indirect comparisons.
We conducted a search of the PubMed, Embase, Cochrane Library, Scopus, Web of Science, China National Knowledge Infrastructure, Wanfang, VIP, and China Biomedical Literature databases for randomized controlled trials up to November 12, 2024. The using search terms were: white light, blue light, green light, and SAD/winter depression. Two independent researchers reviewed and extracted the data.
After screening, a total of 17 studies were obtained, involving 773 patients. These studies included 14 on white light, 6 on blue light, 2 on green light, and 5 on red light. The results indicated that, in terms of alleviating seasonal mood dysregulation or typical depressive symptoms, white light therapy was most effective, followed by green light, blue light and red light. Furthermore, usual care of SAD was found to be more effective than green light therapy in improving seasonal mood dysregulation.
The existing evidence suggests that white light may be the best visible light therapy for patients with SAD, with usual care being more effective than green light. However, larger-scale studies are still needed to verify the potential differences among green light and blue light, further comprehensively evaluate the effectiveness of visible light at different wavelengths for SAD.
通过直接和间接比较来确定不同可见光疗法治疗季节性情感障碍（SAD）的疗效。
我们检索了截至2024年11月12日的PubMed、Embase、Cochrane图书馆、Scopus、Web of Science、中国知网、万方、维普和中国生物医学文献数据库中的随机对照试验。使用的检索词为：白光、蓝光、绿光和SAD/冬季抑郁。两名独立研究人员对数据进行了审查和提取。
经过筛选，共获得17项研究，涉及773名患者。这些研究包括14项关于白光的研究、6项关于蓝光的研究、2项关于绿光的研究和5项关于红光的研究。结果表明，在缓解季节性情绪失调或典型抑郁症状方面，白光疗法最有效，其次是绿光、蓝光和红光。此外，发现SAD的常规护理在改善季节性情绪失调方面比绿光疗法更有效。
现有证据表明，白光可能是SAD患者最佳的可见光疗法，常规护理比绿光更有效。然而，仍需要更大规模的研究来验证绿光和蓝光之间的潜在差异，进一步全面评估不同波长可见光对SAD的有效性。
