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针对患有边缘型人格障碍的女性和分娩者的围产期情绪技能小组:一项可行性随机对照试验的结果

Perinatal emotional skills groups for women and birthing people with borderline personality disorder: outcomes from a feasibility randomised controlled trial.

作者信息

Moran Paul, Bick Debra, Biddle Lucy, Borries Belinda, Kandiyali Rebecca, Mgaieth Farah, Patel Vivan, Rigby Janice, Seume Penny, Sadhnani Vaneeta, Smith Nadine, Swales Michaela, Turner Nicholas

机构信息

Centre for Academic Mental Health, Population Health Sciences Department, Bristol Medical School, University of Bristol, UK.

Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, UK.

出版信息

BJPsych Open. 2024 Dec 26;11(1):e12. doi: 10.1192/bjo.2024.833.

Abstract

BACKGROUND

There is no clear evidence about how to support people with borderline personality disorder (BPD) during the perinatal period. Perinatal emotional skills groups (ESGs) may be helpful, but their efficacy has not been tested.

AIMS

To test the feasibility of conducting a randomised controlled trial (RCT) of perinatal ESGs for women and birthing people with BPD.

METHOD

Two-arm parallel-group feasibility RCT. We recruited people from two centres, aged over 18 years, meeting DSM-5 diagnostic criteria for BPD, who were pregnant or within 12 months of a live birth. Eligible individuals were randomly allocated on a 1:1 ratio to ESGs + treatment as usual (TAU), or to TAU. Outcomes were assessed at 4 months post randomisation.

RESULTS

A total of 100% of the pre-specified sample ( = 48) was recruited over 6 months, and we obtained 4-month outcome data on 92% of randomised participants. In all, 54% of participants allocated to perinatal ESGs attended 75% of the full group treatment (median number of sessions: 9 (interquartile range 6-11). At 4 months, levels of BPD symptoms (adjusted coefficient -2.0, 95% CI -6.2 to 2.1) and emotional distress (-2.4, 95% CI -6.2 to 1.5) were lower among those allocated to perinatal ESGs. The directionality of effect on well-being and social functioning also favoured the intervention. The cost of delivering perinatal ESGs was estimated to be £918 per person.

CONCLUSIONS

Perinatal ESGs may represent an effective intervention for perinatal women and birthing people with BPD. Their efficacy should be tested in a fully powered RCT, and this is a feasible undertaking.

TRIAL REGISTRATION

ISRCTN80470632.

摘要

背景

关于如何在围产期为边缘型人格障碍(BPD)患者提供支持,目前尚无明确证据。围产期情绪技能小组(ESGs)可能会有所帮助,但其疗效尚未得到检验。

目的

测试针对患有BPD的孕妇和产妇开展围产期ESGs随机对照试验(RCT)的可行性。

方法

双臂平行组可行性RCT。我们从两个中心招募年龄超过18岁、符合DSM-5 BPD诊断标准、怀孕或在活产后12个月内的人群。符合条件的个体按1:1比例随机分配至ESGs+常规治疗(TAU)组或TAU组。在随机分组后4个月评估结果。

结果

在6个月内招募了100%的预先指定样本(n = 48),我们获得了92%随机分组参与者的4个月结果数据。总体而言,分配到围产期ESGs组的参与者中有54%参加了75%的完整小组治疗(疗程中位数:9次(四分位间距6 - 11次))。在4个月时,分配到围产期ESGs组的参与者的BPD症状水平(调整系数 -2.0,95%置信区间 -6.2至2.1)和情绪困扰(-2.4,95%置信区间 -6.2至1.5)较低。对幸福感和社会功能的影响方向也有利于该干预措施。围产期ESGs的实施成本估计为每人918英镑。

结论

围产期ESGs可能是针对患有BPD的围产期妇女和产妇的有效干预措施。其疗效应在一项充分有力的RCT中进行检验,这是一项可行的工作。

试验注册

ISRCTN80470632

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd88/11733485/877cfb5bd9e3/S2056472424008330_fig1.jpg

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