Hayashi N, Kasahara A, Kurosawa K, Sasaki Y, Fusamoto H, Sato N, Kamada T
Gastroenterology. 1985 Apr;88(4):881-6. doi: 10.1016/s0016-5085(85)80003-2.
In the present study we have investigated hepatic hemodynamics in patients with alcoholic liver disease using reflectance spectrophotometry and the hydrogen clearance method. Analysis of 38 cases has shown that estimated regional hepatic-tissue hemoglobin concentration, expressed as a difference in absorbance between 569 and 650 nm (delta Er569-650), decreased significantly with progress of fibrosis or fat accumulation in the liver. This suggests that the relative compression of the vascular compartment is due to the progress of alcoholic liver disease. Estimated hepatic hemoglobin concentration also correlated positively with prothrombin time, and negatively with serum gamma-globulin level and 15-min retention rate of indocyanine green. The difference in absorbance between 569 and 650 nm obtained by reflectance spectrophotometry was positively correlated with the regional hepatic blood flow as measured by the hydrogen clearance method. Thus, it is concluded that the estimated regional hepatic-tissue hemoglobin concentration decreases with progress of fibrosis and fat accumulation in the liver, and that this decreased oxygen supply to the liver may have an important role in the progress of alcoholic liver disease.
在本研究中，我们使用反射分光光度法和氢清除法对酒精性肝病患者的肝脏血流动力学进行了研究。对38例患者的分析表明，以569至650nm吸光度差值表示的估计局部肝组织血红蛋白浓度（δEr569 - 650），随着肝脏纤维化或脂肪堆积的进展而显著降低。这表明血管腔的相对受压是由于酒精性肝病的进展所致。估计的肝血红蛋白浓度还与凝血酶原时间呈正相关，与血清γ-球蛋白水平及吲哚菁绿15分钟潴留率呈负相关。通过反射分光光度法获得的569至650nm吸光度差值与用氢清除法测得的局部肝血流量呈正相关。因此，得出结论，估计的局部肝组织血红蛋白浓度随着肝脏纤维化和脂肪堆积的进展而降低，并且肝脏氧供应的减少可能在酒精性肝病的进展中起重要作用。
