Sasaki Y, Hayashi N, Kasahara A, Matsuda Y, Furusawa S, Fusamoto H, Sato N, Kamada T
Dig Dis Sci. 1985 Nov;30(11):1043-8. doi: 10.1007/BF01315601.
The influence of the intravenous injection of ranitidine (50 mg) on hepatic hemodynamics was investigated in normal subjects and patients with chronic liver disease. Using the organ-reflectance spectrophotometer, the regional hepatic blood hemoglobin concentration (delta Er569-650), an indicator of the regional hepatic blood flow, and the oxygen saturation of hemoglobin in the regional hepatic tissue (So2) were measured in patients with chronic liver disease after ranitidine injection under peritoneoscopy. With the pulse-Doppler ultrasonic flowmeter, the portal blood flow was measured in patients with chronic liver disease and normal subjects. There were no significant changes in the regional hepatic blood flow, the oxygen saturation of hemoglobin, and the portal blood flow after the intravenous injection of ranitidine. Thus, it is concluded that usual dose of ranitidine has no significant influence on the hepatic blood flow and that it can be prescribed without reducing the hepatic blood flow.
在正常受试者和慢性肝病患者中研究了静脉注射雷尼替丁（50毫克）对肝脏血流动力学的影响。使用器官反射分光光度计，在腹腔镜检查下对慢性肝病患者注射雷尼替丁后，测量局部肝血流的指标——局部肝血血红蛋白浓度（δEr569 - 650）以及局部肝组织中血红蛋白的氧饱和度（So2）。使用脉冲多普勒超声流量计，测量慢性肝病患者和正常受试者的门静脉血流。静脉注射雷尼替丁后，局部肝血流、血红蛋白氧饱和度和门静脉血流均无显著变化。因此，得出结论：常规剂量的雷尼替丁对肝血流无显著影响，可在不减少肝血流的情况下开具处方。
