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“我仍能感觉到不适”:美沙酮维持治疗者的戒断经历

"I still can feel the sickness": Withdrawal experiences of people on methadone maintenance treatment.

作者信息

Frank David, Bennett Alex S, Cleland Charles M, Meyerson Beth E, Russell Danielle M, Walters Suzan M, Simon Caty, Scheidell Joy D, Elliott Luther

机构信息

Department of Social and Behavioral Sciences, School of Global Public Health, New York University, New York, NY 10003, USA; Center for Drug Use and HIV/HCV Research, School of Global Public Health, New York University, New York, NY 10003, USA; Harm Reduction Research Lab, Department of Family and Community Medicine, College of Medicine, University of Arizona, Tucson, AZ 85711, USA.

Department of Social and Behavioral Sciences, School of Global Public Health, New York University, New York, NY 10003, USA; Center for Drug Use and HIV/HCV Research, School of Global Public Health, New York University, New York, NY 10003, USA; Center for Anti-racism, Social Justice, and Public Health, School of Global Public Health, New York University, New York, NY 10003, USA.

出版信息

J Subst Use Addict Treat. 2025 Mar;170:209616. doi: 10.1016/j.josat.2024.209616. Epub 2024 Dec 23.

Abstract

INTRODUCTION

Opioid withdrawal is a regular occurrence for many people who use illicit opioids (PWUIO) involving acute physical and psychological pain. Yet, there is very little data on the withdrawal experience of people in methadone maintenance treatment (MMT) and almost none from the patients' experience. Learning more about patients' withdrawal experiences can help to inform policies and practices that are better suited to address withdrawal and may improve patient satisfaction as well as uptake and retention.

METHODS

This article is based on 29 semi-structured interviews with people who use illicit opioids who reported recent withdrawal experience. The study conducted interviews remotely via Zoom between April and August 2022 and later transcribed them professionally. The study team then coded data thematically using Atlas.ti, based on a combination of inductive and deductive coding strategies and informed by the literature and study aims.

RESULTS

Participants described withdrawal as a significant issue that negatively impacts their treatment experience and increases the likelihood of treatment cessation. Their accounts of withdrawal were complex and often involved multiple factors; however, feeling underdosed and missing clinic dosing hours were seen as important vectors that led to their withdrawal experiences. Importantly, participants framed feeling underdosed and missing clinic dosing hours as institutional problems, resulting primarily from clinic policies, practices, and culture rather than from patients' decisions or individual behavior. Specifically, they cited restricted access to take-home doses, limited hours of operation, and a punitive focus on complete abstinence as factors that made withdrawal difficult to avoid.

CONCLUSIONS

Patients' accounts demonstrate a disconnect between providers' focus on promoting complete abstinence and patients, who were often using MMT for more pragmatic reasons that did not include complete abstinence from all drugs. These findings support growing calls for the integration of MMT into the mainstream healthcare system by making it available via prescription from office-based medical settings and dispensed through pharmacies.

摘要

引言

对于许多使用非法阿片类药物的人(PWUIO)来说,阿片类药物戒断是常有的事,会带来急性身体和心理疼痛。然而,关于接受美沙酮维持治疗(MMT)的人的戒断经历的数据非常少,几乎没有来自患者自身经历的相关数据。更多地了解患者的戒断经历有助于制定更适合应对戒断问题的政策和做法,可能会提高患者满意度以及治疗的接受度和留存率。

方法

本文基于对29名有近期戒断经历的使用非法阿片类药物者进行的半结构化访谈。该研究于2022年4月至8月通过Zoom远程进行访谈,随后进行专业转录。研究团队随后基于归纳和演绎编码策略的结合,并参考文献和研究目的,使用Atlas.ti对数据进行主题编码。

结果

参与者将戒断描述为一个严重问题,对他们的治疗体验产生负面影响,并增加了治疗中断的可能性。他们对戒断的描述很复杂,通常涉及多个因素;然而,感觉剂量不足和错过诊所给药时间被视为导致他们戒断经历的重要因素。重要的是,参与者将感觉剂量不足和错过诊所给药时间视为机构问题,主要是由诊所政策、做法和文化导致的,而非患者的决定或个人行为。具体而言,他们指出带回家剂量的获取受限、营业时间有限以及对完全禁欲的惩罚性关注是导致难以避免戒断的因素。

结论

患者的描述表明,提供者对促进完全禁欲的关注与患者之间存在脱节,患者通常出于更务实的原因接受美沙酮维持治疗,这些原因并不包括完全戒除所有药物。这些发现支持了越来越多的呼声,即通过在门诊医疗环境中开具处方并通过药房配药,将美沙酮维持治疗纳入主流医疗体系。

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