Liu Hao, Zhao Hongyu, Zhou Mingzhen, Zhao Xiaodi, Lu Yuanyuan
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, 710032, Xi'an, Shaanxi, China.
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, National Clinical Research Center for Digestive Diseases, Xijing Hospital, Fourth Military Medical University, 710032, Xi'an, Shaanxi, China.
Cancer Lett. 2024 Dec 23;611:217417. doi: 10.1016/j.canlet.2024.217417.
The tumor microenvironment (TME) is closely associated with the therapeutic response and clinical outcome of cancer drug therapies, which mainly include immunotherapy, chemotherapy and targeted therapy. Neutrophils that infiltrate tumors, also known as tumor-associated neutrophils (TANs), constitute a primary part of the TME. However, the functional importance of TANs in cancer drug therapy has long been overlooked because of their relatively short life span. Recent studies have shown that TANs play crucial protumoral or antitumoral roles in cancer drug treatment, largely because of their diversity and plasticity. This review describes the development, heterogeneity and recruitment of neutrophils in the context of cancer and emphasizes the role and mechanisms of TANs in cancer drug resistance. Additionally, several potential neutrophil-targeted strategies are discussed.
肿瘤微环境（TME）与癌症药物治疗的疗效及临床结果密切相关，癌症药物治疗主要包括免疫治疗、化疗和靶向治疗。浸润肿瘤的中性粒细胞，也称为肿瘤相关中性粒细胞（TANs），是肿瘤微环境的主要组成部分。然而，由于TANs寿命相对较短，其在癌症药物治疗中的功能重要性长期以来一直被忽视。最近的研究表明，TANs在癌症药物治疗中发挥着关键的促肿瘤或抗肿瘤作用，这主要是由于它们的多样性和可塑性。本文综述了癌症背景下中性粒细胞的发育、异质性和募集，并强调了TANs在癌症耐药性中的作用和机制。此外，还讨论了几种潜在的针对中性粒细胞的策略。
