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通过在药物数据解读中运用自然语言处理(NLP)和机器学习的强大功能进行高级分析,以加强药物研发和患者护理。

Enhancing drug discovery and patient care through advanced analytics with the power of NLP and machine learning in pharmaceutical data interpretation.

作者信息

R Nagalakshmi, Khan Surbhi Bhatia, Kumar Ananthoju Vijay, T R Mahesh, Alojail Mohammad, Sangwan Saurabh Raj, Saraee Mo

机构信息

Department of Data Science, School of Science Engineering and Environment, University of Salford, Manchester, United Kingdom.

University Centre for Research and Development, Chandigarh University, Mohali, Punjab, India; Centre for Research Impact and Outcome and Chitkara University Institute of Engineering and Technology and Chitkara University, Rajpura, 140401, Punjab, India.

出版信息

SLAS Technol. 2025 Apr;31:100238. doi: 10.1016/j.slast.2024.100238. Epub 2024 Dec 24.

DOI:10.1016/j.slast.2024.100238
PMID:39722407
Abstract

This study delves into the transformative potential of Machine Learning (ML) and Natural Language Processing (NLP) within the pharmaceutical industry, spotlighting their significant impact on enhancing medical research methodologies and optimizing healthcare service delivery. Utilizing a vast dataset sourced from a well-established online pharmacy, this research employs sophisticated ML algorithms and cutting-edge NLP techniques to critically analyze medical descriptions and optimize recommendation systems for drug prescriptions and patient care management. Key technological integrations include BERT embeddings, which provide nuanced contextual understanding of complex medical texts, and cosine similarity measures coupled with TF-IDF vectorization to significantly enhance the precision and reliability of text-based medical recommendations. By meticulously adjusting the cosine similarity thresholds from 0.2 to 0.5, our tailored models have consistently achieved a remarkable accuracy rate of 97 %, illustrating their effectiveness in predicting suitable medical treatments and interventions. These results not only highlight the revolutionary capabilities of NLP and ML in harnessing data-driven insights for healthcare but also lay a robust groundwork for future advancements in personalized medicine and bespoke treatment pathways. Comprehensive analysis demonstrates the scalability and adaptability of these technologies in real-world healthcare settings, potentially leading to substantial improvements in patient outcomes and operational efficiencies within the healthcare system.

摘要

本研究深入探讨了机器学习(ML)和自然语言处理(NLP)在制药行业中的变革潜力,突出了它们对改进医学研究方法和优化医疗服务提供的重大影响。本研究利用从一家成熟的在线药房获取的大量数据集,采用先进的ML算法和前沿的NLP技术,对医学描述进行批判性分析,并优化药物处方和患者护理管理的推荐系统。关键的技术整合包括BERT嵌入,它能提供对复杂医学文本的细微上下文理解,以及结合TF-IDF矢量化的余弦相似度度量,以显著提高基于文本的医学推荐的精度和可靠性。通过精心将余弦相似度阈值从0.2调整到0.5,我们定制的模型始终达到了97%的显著准确率,说明了它们在预测合适的医学治疗和干预措施方面的有效性。这些结果不仅突出了NLP和ML在利用数据驱动的见解促进医疗保健方面的革命性能力,也为个性化医疗和定制治疗途径的未来发展奠定了坚实基础。全面分析表明了这些技术在现实世界医疗环境中的可扩展性和适应性,有可能大幅改善医疗系统中的患者预后和运营效率。

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引用本文的文献

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The Potential of Artificial Intelligence in Pharmaceutical Innovation: From Drug Discovery to Clinical Trials.人工智能在药物创新中的潜力:从药物发现到临床试验
Pharmaceuticals (Basel). 2025 May 25;18(6):788. doi: 10.3390/ph18060788.