Tu Jingyi, Shen Changqing, Lei Ruiling, Yang Jie, Wang Shicheng, Peng Siqi, Li Lang, Qiu Xiaoyan
Chongqing Key Laboratory of Herbivore Science, College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, Yunnan, China.
Sheng Wu Gong Cheng Xue Bao. 2024 Dec 25;40(12):4452-4466. doi: 10.13345/j.cjb.240128.
Embryo implantation involves a complex interaction between the embryo and the endometrium of the mother, the study of which faces a variety of problems. The modeling of endometrial epithelial organoids and endometrial assembloids provides a new way to study the process of embryo implantation . This paper summarized the latest research progress in embryo implantation, the regulation mechanism of endometrial receptivity by estrogen- progesterone coordination and embryo-derived signals, the establishment of endometrial organoids, and the development and application of endometrial assembloids in the research on mother-embryo interaction, providing new strategies for studying the communication between embryo and maternal uterus during implantation.
胚胎着床涉及胚胎与母体子宫内膜之间复杂的相互作用，对其研究面临着诸多问题。子宫内膜上皮类器官和子宫内膜组装体的建模为研究胚胎着床过程提供了新途径。本文综述了胚胎着床的最新研究进展、雌激素 - 孕激素协同作用和胚胎来源信号对子宫内膜容受性的调控机制、子宫内膜类器官的建立以及子宫内膜组装体在母胎相互作用研究中的发展与应用，为研究着床期间胚胎与母体子宫之间的通讯提供了新策略。
