Steinhardt M
Gerontology. 1985;31(1):27-38. doi: 10.1159/000212678.
Human skin fibroblasts of about the same population doubling level, derived from donors of different age, were cloned. After 14 days of growth, the clones were morphologically classified, and cell counts were performed. Significant differences between the three age groups (infant, young adult, old adult) examined concerned the percentual clone type distribution. The size of a single clone depended on the clone type referring to the differentiation level of the cells in all age groups.
对来自不同年龄供体、处于大致相同群体倍增水平的人皮肤成纤维细胞进行克隆。生长14天后，对克隆进行形态学分类并进行细胞计数。所检测的三个年龄组（婴儿、青年成人、老年成人）之间的显著差异涉及克隆类型分布百分比。在所有年龄组中，单个克隆的大小取决于与细胞分化水平相关的克隆类型。
