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胰高血糖素样肽-1受体激动剂治疗患者胃肠道症状管理的饮食建议

Dietary Recommendations for the Management of Gastrointestinal Symptoms in Patients Treated with GLP-1 Receptor Agonist.

作者信息

Gentinetta Silvia, Sottotetti Francesca, Manuelli Matteo, Cena Hellas

机构信息

Novo Nordisk Italia SpA, Roma, Italy.

Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.

出版信息

Diabetes Metab Syndr Obes. 2024 Dec 19;17:4817-4824. doi: 10.2147/DMSO.S494919. eCollection 2024.

Abstract

GLP-1 receptor agonist (GLP-1RA) have been developed to address the global burden of obesity and are renowned for their safety and efficacy. These medications influence hunger and satiety, reducing energy intake and promoting weight loss. Despite their benefits, GLP-1RAmay cause a slowed gastric emptying, leading to gastrointestinal symptoms. This study examines how food properties and meal composition affect these symptoms. Dietary recommendations are provided, particularly for evening meals, focusing on how different foods and nutrients can influence the rate of gastric emptying, to improve patient compliance and prevent interruption in weight loss.

摘要

胰高血糖素样肽-1受体激动剂(GLP-1RA)已被研发用于应对全球肥胖负担,并且以其安全性和有效性而闻名。这些药物会影响饥饿感和饱腹感,减少能量摄入并促进体重减轻。尽管它们有诸多益处,但GLP-1RA可能会导致胃排空减慢,从而引发胃肠道症状。本研究探讨食物特性和膳食组成如何影响这些症状。文中提供了饮食建议,特别是针对晚餐的建议,重点关注不同食物和营养素如何影响胃排空速率,以提高患者的依从性并防止体重减轻过程受到干扰。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ec06/11668918/6601e80f04eb/DMSO-17-4817-g0001.jpg

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