Rajaragupathy Sujatha, Ponnusamy Deepika, Balasundararaj Dhanalakshmi, Venkatesan Sandhiya, Karthikeyan Jayagowri
Department of Biochemistry, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
Department of Community Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India.
J Family Med Prim Care. 2024 Nov;13(11):5240-5243. doi: 10.4103/jfmpc.jfmpc_989_24. Epub 2024 Nov 18.
Low-density lipoprotein receptor-related protein-2 (LRP2), also called megalin, is a multi-ligand receptor of the LDL receptor gene family mediating reabsorption of ligands like Apo-A1. Type 2 diabetes mellitus (T2DM) may possibly disrupt megalin functions as it is found to be regulated by insulin. This might cause cardiovascular complications due to derangement in lipoprotein metabolism. The current study was carried out to assess the serum megalin levels among T2DM individuals with cardiovascular complications in the Indian population.
This was a cross-sectional study involving 80 patients with T2DM. 40 T2DM patients with known cardiovascular disease were selected as cases and 40 of those without evidence of cardiovascular disease were selected as controls. Demographic details, DM duration and class of oral hypoglycemic agents (OHA) used were collected from medical records while details of lipid profile, fasting glucose, serum creatinine and urea were collected from laboratory information system. Serum megalin levels were estimated using left-over samples by ELISA.
The study groups showed no statistical significance in baseline laboratory parameters except for serum creatinine and low density lipoprotein cholesterol (LDL-c). Mean serum megalin levels were statistically insignificant between cases and controls (0.91 ± 0.78 ng/mL vs. 0.85 ± 0.69 ng/mL, 0.74).The subgroup analysis of serum megalin levels based on OHA consumption among cases was also statistically insignificant ( 0.056). Pearson's correlational analysis was statistically insignificant between serum megalin and lipid profile parameters among cases ( > 0.05).
Serum megalin alone may not serve as a biomarker for cardiovascular disease.
低密度脂蛋白受体相关蛋白2（LRP2），也称为巨膜蛋白，是低密度脂蛋白受体基因家族的多配体受体，介导载脂蛋白A1等配体的重吸收。2型糖尿病（T2DM）可能会破坏巨膜蛋白的功能，因为发现它受胰岛素调节。这可能会因脂蛋白代谢紊乱而导致心血管并发症。本研究旨在评估印度人群中患有心血管并发症的T2DM患者的血清巨膜蛋白水平。
这是一项横断面研究，涉及80例T2DM患者。选择40例已知患有心血管疾病的T2DM患者作为病例组，40例无心血管疾病证据的患者作为对照组。从病历中收集人口统计学细节、糖尿病病程和使用的口服降糖药（OHA）类别，同时从实验室信息系统收集血脂谱、空腹血糖、血清肌酐和尿素的详细信息。使用酶联免疫吸附测定法（ELISA）对剩余样本进行血清巨膜蛋白水平测定。
除血清肌酐和低密度脂蛋白胆固醇（LDL-c）外，研究组在基线实验室参数方面无统计学意义。病例组和对照组的平均血清巨膜蛋白水平无统计学意义（0.91±0.78 ng/mL对0.85±0.69 ng/mL，P = 0.74）。病例组中基于OHA使用情况的血清巨膜蛋白水平亚组分析也无统计学意义（P = 0.056）。病例组中血清巨膜蛋白与血脂谱参数之间的Pearson相关性分析无统计学意义（P>0.05）。
仅血清巨膜蛋白可能无法作为心血管疾病的生物标志物。
