Velusami Deepika, Krishnamurthy Soundariya, Abiharini Subramoniam
Department of Physiology, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India.
Department of Physiology, Sri Manakula Vinayagar Medical College and Hospital, Madagadipet, Puducherry, India.
J Family Med Prim Care. 2024 Nov;13(11):5320-5324. doi: 10.4103/jfmpc.jfmpc_954_24. Epub 2024 Nov 18.
PCOS is one of the most neglected noncommunicable diseases, and early detection would be of great value to primary care physicians. Sympathovagal imbalance detected using heart rate variability (HRV) can be used to detect early autonomic changes if any.
The present study aimed to evaluate QTc and Poincare plot (nonlinear analysis of HRV) in young adolescent PCOS patients.
It was a cross-sectional study involving 25 PCOS and 25 healthy individuals of age group 12-18 years. HRV was evaluated using the lead II ECG for 10 min from which QTc was calculated manually using the Bazett formula. Student's -test was used to assess differences between means. A value < 0.05 was taken for statistical significance. The association between QTc and Poincare plot descriptors was assessed by Pearson's correlation analysis.
HRV linear analysis domain represented as the LF/HF ratio was reported to significantly increased among the PCOS group ( = 0.04). Similarly, the nonlinear analysis of HRV by Poincare plot reported a significant decrease in SD1 ( = 0.04) and SD2 ( = 0.02). The heart rate was significantly increased among the PCOS group ( < 0.001). QTc did not show any significant increase among the PCOS group ( = 0.09). QTc was reported to be positively correlated with SD1 (r = 0.37, < 0.01), SD2 (r-0.33, = 0.02), LF HF ratio (r = 0.52, < 0.001), and BMI (r = 0.92, < 0.001), respectively.
The study suggests that HRV nonlinear analysis can be used as a simple noninvasive tool to evaluate cardiovascular autonomic changes.
多囊卵巢综合征（PCOS）是最被忽视的非传染性疾病之一，早期检测对初级保健医生具有重要价值。使用心率变异性（HRV）检测到的交感迷走神经失衡可用于检测早期自主神经变化（如有）。
本研究旨在评估年轻青春期PCOS患者的QTc和庞加莱图（HRV的非线性分析）。
这是一项横断面研究，涉及25名PCOS患者和25名年龄在12 - 18岁的健康个体。使用II导联心电图评估HRV 10分钟，并用Bazett公式手动计算QTc。采用学生t检验评估均值差异。P值<0.05具有统计学意义。通过Pearson相关分析评估QTc与庞加莱图描述符之间的关联。
据报道，PCOS组中以低频/高频（LF/HF）比值表示的HRV线性分析域显著增加（P = 0.04）。同样，通过庞加莱图对HRV进行的非线性分析显示，SD1（P = 0.04）和SD2（P = 0.02）显著降低。PCOS组的心率显著增加（P < 0.001）。PCOS组的QTc未显示出任何显著增加（P = 0.09）。据报道，QTc分别与SD1（r = 0.37，P < 0.01）、SD2（r = 0.33，P = 0.02）、LF/HF比值（r = 0.52，P < 0.001）和体重指数（BMI）（r = 0.92，P < 0.001）呈正相关。
该研究表明，HRV非线性分析可作为评估心血管自主神经变化的一种简单无创工具。
