Bharali Mintu Dewri, Rajendran Radhika, Goswami Jayshree, Singal Kusum, Rajendran Vinoth
Department of Community Medicine, Guwahati Medical College and Hospital, Guwahati, IND.
Department of Biotechnology, Indian Institute of Technology, Guwahati, Guwahati, IND.
Cureus. 2022 Dec 9;14(12):e32351. doi: 10.7759/cureus.32351. eCollection 2022 Dec.
Stein-Leventhal syndrome, often known as polycystic ovarian syndrome (PCOS), is a syndrome that affects women's reproductive health. PCOS is one of the most common endocrine and metabolic disorders in women of reproductive age. The etiology of PCOS remains unknown mainly, and the estimation of PCOS burden in a specific geographical location will impact disease control strategies. Hence, this study estimated the pooled prevalence of PCOS in Indian women. Databases such as PubMed, CINHAL, Scopus, and Google Scholar were thoroughly searched. Only those published Indian studies that reported the prevalence of PCOS from 2010 to 2021 and had at least one of the following diagnostic PCOS criteria were included in the systematic review: the National Institutes of Health (NIH), Rotterdam's criteria, or/and Androgen Excess Society (AES). MetaXL version 5.3 software was used for data analysis. The risk of bias was assessed using modified Joanna Briggs Institute criteria for cross-sectional studies. Out of 17132 articles, 11 articles were selected for systematic review and meta-analysis. The pooled prevalence of PCOS was 11.33(7.69-15.59) using the random effect. The proportion of Hirsute using the Ferriman-Gallwey score was highly variable, ranging from 1.6% to 37.9% (n=6). The prevalence rate of PCOS is high among Indian women. The pooled prevalence of PCOS was close to 10% using Rotterdam's criteria and AES criteria, while it was 5.8% using NIH criteria. The study's overall finding emphasizes the need for more acceptable and uniform diagnostic criteria for screening PCOS. At the same time, policy-makers should consider giving more importance to PCOS in their effort to control non-communicable diseases.
斯坦因-莱文塔尔综合征，通常被称为多囊卵巢综合征（PCOS），是一种影响女性生殖健康的综合征。PCOS是育龄女性中最常见的内分泌和代谢紊乱疾病之一。PCOS的病因主要仍不明确，特定地理位置的PCOS负担估计将影响疾病控制策略。因此，本研究估计了印度女性中PCOS的合并患病率。对PubMed、CINHAL、Scopus和谷歌学术等数据库进行了全面检索。纳入系统评价的仅为那些2010年至2021年发表的、报告了PCOS患病率且至少符合以下PCOS诊断标准之一的印度研究：美国国立卫生研究院（NIH）标准、鹿特丹标准或/和雄激素过多协会（AES）标准。使用MetaXL 5.3版软件进行数据分析。采用修改后的乔安娜·布里格斯研究所横断面研究标准评估偏倚风险。在17132篇文章中，选择了11篇进行系统评价和荟萃分析。采用随机效应模型，PCOS的合并患病率为11.33（7.69 - 15.59）。使用费里曼-盖尔韦评分法评估多毛症的比例差异很大，范围为1.6%至37.9%（n = 6）。印度女性中PCOS的患病率较高。采用鹿特丹标准和AES标准时，PCOS的合并患病率接近10%，而采用NIH标准时为5.8%。该研究的总体发现强调需要更可接受和统一的PCOS筛查诊断标准。同时，政策制定者在控制非传染性疾病的努力中应考虑更加重视PCOS。
