Zhang Jinjin, Liu Yuhan, Zhang Jiawei, Zeng Fei, Wu Yuqing, Zhang Xuexue, Zhang Daying, Zhu Mengye
Department of Pain Medicine Ji'an Central People's Hospital Ji'an China.
Key Laboratory of Neuropathic Pain, Healthcare Commission of Jiangxi Province Nanchang China.
Food Sci Nutr. 2024 Nov 1;12(12):10223-10230. doi: 10.1002/fsn3.4574. eCollection 2024 Dec.
Previous observational studies focused on the association of tea intake and allergic diseases. However, it is not known whether these associations are causal. We used a bidirectional Mendelian randomization (MR) study to assess the causal relationship of tea intake with the risk of allergic diseases, such as atopic dermatitis (AD), allergic rhinitis (AR), and allergic asthma (AA). Single-nucleotide polymorphisms (SNPs) which had genetic statistical significance with tea intake were used as instrumental variables (IVs). We employed heritable IVs of tea intake from the UK Biobank, which included 447,485 samples. Sensitivity analyses were further performed using MR Egger and MR-PRESSO. Inverse variance weighted (IVW) method was used as the main approach. In this MR study, 40 independent SNPs were selected for tea intake. The MR analysis revealed that an increase in genetically predicted tea intake was associated with a lower risk of AD (OR = 0.709, 95% CI = 0.546-0.919, = 0.009). Furthermore, we observed a causal effect of genetically predicted tea intake on the risk of AA (OR = 0.498, 95% CI = 0.320-0.776, = 0.002). However, no significant causal relationship was found between genetically predicted tea intake and AR (OR = 1.008, 95% CI = 0.998-1.017, = 0.115). Our MR analysis suggested that increased tea intake may reduce the risk of AD and AA in European population. This suggests that tea intake is likely a trigger or a prevention strategy for AD and AA.
以往的观察性研究聚焦于茶摄入量与过敏性疾病之间的关联。然而，这些关联是否具有因果关系尚不清楚。我们采用双向孟德尔随机化（MR）研究来评估茶摄入量与过敏性疾病风险之间的因果关系，这些过敏性疾病包括特应性皮炎（AD）、过敏性鼻炎（AR）和过敏性哮喘（AA）。与茶摄入量具有遗传统计学意义的单核苷酸多态性（SNP）被用作工具变量（IV）。我们使用了英国生物银行中茶摄入量的遗传性IV，该生物银行包含447,485个样本。使用MR Egger和MR-PRESSO进一步进行敏感性分析。采用逆方差加权（IVW）方法作为主要分析方法。在这项MR研究中，选择了40个与茶摄入量相关的独立SNP。MR分析显示，遗传预测的茶摄入量增加与AD风险降低相关（OR = 0.709，95% CI = 0.546 - 0.919，P = 0.009）。此外，我们观察到遗传预测的茶摄入量对AA风险有因果效应（OR = 0.498，95% CI = 0.320 - 0.776，P = 0.002）。然而，在遗传预测的茶摄入量与AR之间未发现显著的因果关系（OR = 1.008，95% CI = 0.998 -
