Fang Meisi, Ma Jinghang, Bai Yongyu, Ying Yifan, Shen Xian, Feng Zhen
School of the First Clinical Medical Sciences (School of Information and Engineering) Wenzhou Medical University Wenzhou China.
Department of Gastrointestinal Surgery the First Affiliated Hospital of Wenzhou Medical University Wenzhou China.
Food Sci Nutr. 2024 Nov 25;12(12):10786-10799. doi: 10.1002/fsn3.4613. eCollection 2024 Dec.
Sarcopenia, characterized by an age-related progressive loss of muscle mass and strength, presents significant health concerns. Recommending dietary nutrition emerges as a viable strategy to counteract muscle deterioration. Vitamin A, indispensable throughout the human life cycle and unattainable through endogenous synthesis, necessitates intake via diet. However, the direct correlation between sarcopenia prevalence and vitamin A intake remains unclear. This study systematically investigated the relationship between sarcopenia prevalence and vitamin A intake, including retinol and some carotenoids, across diverse races and genders utilizing multiple statistical analyses. Mixture analysis revealed significant positive correlations between total vitamin A intake and muscle mass among American adult males (Male: OR: 1.019, 95% CI: 1.010-1.027, < 0.001). We also observed the gender-specific results, with retinol playing a more significant role in enhancing muscle mass for males, while certain carotenoids were found to be more influential in females. Moreover, inflammation and oxidative stress mediated the relationship between vitamin A intake and sarcopenia prevalence in both genders. There may be a gender- and race-specific relationship between dietary vitamin A intake and sarcopenia. Further prospective studies are imperative to elucidate the association between vitamin A intake and sarcopenia prevalence.
肌肉减少症的特征是与年龄相关的肌肉质量和力量逐渐丧失，这引发了重大的健康问题。推荐饮食营养成为对抗肌肉退化的一种可行策略。维生素A在人类整个生命周期中不可或缺，且无法通过内源性合成获得，因此必须通过饮食摄入。然而，肌肉减少症患病率与维生素A摄入量之间的直接关联仍不清楚。本研究利用多种统计分析方法，系统地调查了不同种族和性别的肌肉减少症患病率与维生素A摄入量（包括视黄醇和一些类胡萝卜素）之间的关系。混合分析显示，美国成年男性的总维生素A摄入量与肌肉质量之间存在显著正相关（男性：比值比：1.019，95%置信区间：1.010 - 1.027，P < 0.001）。我们还观察到了性别特异性结果，视黄醇对男性增加肌肉质量的作用更为显著，而某些类胡萝卜素对女性的影响更大。此外，炎症和氧化应激介导了维生素A摄入量与男女肌肉减少症患病率之间的关系。饮食中维生素A摄入量与肌肉减少症之间可能存在性别和种族特异性关系。进一步的前瞻性研究对于阐明维生素A摄入量与肌肉减少症患病率之间的关联至关重要。
