Bǎcilǎ Ciprian-Ionuț, Marcu Gabriela Mariana, Vintilă Bogdan Ioan, Anghel Claudia Elena, Lomnasan Andrei, Cornea Monica, Grama Andreea Maria
Clinical Psychiatry Hospital "Dr. Gheorghe Preda", 550082 Sibiu, Romania.
Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.
J Clin Med. 2025 Jul 22;14(15):5197. doi: 10.3390/jcm14155197.
: Functional near-infrared spectroscopy (fNIRS) is a non-invasive neuroimaging technique with growing relevance in psychiatry. Its ability to measure cortical hemodynamics positions it as a potential tool for monitoring neurofunctional changes related to treatment. However, the specific features and level of consistency of its use in clinical psychiatric settings remain unclear. A scoping review was conducted under PRISMA-ScR guidelines to systematically map how fNIRS has been used in monitoring treatment response among individuals with psychiatric disorders. : Forty-seven studies published between 2009 and 2025 were included based on predefined eligibility criteria. Data was extracted on publication trends, research design, sample characteristics, fNIRS paradigms, signal acquisition, preprocessing methods, and integration of clinical outcomes. Reported limitations and conflicts of interest were also analyzed. : The number of publications increased sharply after 2020, predominantly from Asia. Most studies used experimental designs, with 31.9% employing randomized controlled trials. Adults were the primary focus (93.6%), with verbal fluency tasks and DLPFC-targeted paradigms most common. Over half of the studies used high-density (>32-channel) systems. However, only 44.7% reported motion correction procedures, and 53.2% did not report activation direction. Clinical outcome linkage was explicitly stated in only 12.8% of studies. : Despite growing clinical interest, with fNIRS showing promise as a non-invasive neuroimaging tool for monitoring psychiatric treatment response, the current evidence base is limited by methodological variability and inconsistent outcome integration. There is a rising need for the adoption of standardized protocols for both design and reporting. Future research should also include longitudinal studies and multimodal approaches to enhance validity and clinical relevance.
功能近红外光谱技术（fNIRS）是一种非侵入性神经成像技术，在精神病学领域的相关性日益增加。它测量皮质血流动力学的能力使其成为监测与治疗相关的神经功能变化的潜在工具。然而，其在临床精神病学环境中的具体特征和使用的一致性水平仍不清楚。根据PRISMA-ScR指南进行了一项范围综述，以系统地梳理fNIRS在监测精神障碍患者治疗反应中的应用情况。：根据预先确定的纳入标准，纳入了2009年至2025年发表的47项研究。提取了有关发表趋势、研究设计、样本特征、fNIRS范式、信号采集、预处理方法以及临床结果整合的数据。还分析了报告的局限性和利益冲突。：2020年后发表数量急剧增加，主要来自亚洲。大多数研究采用实验设计，31.9%采用随机对照试验。成年人是主要研究对象（93.6%），语言流畅性任务和针对背外侧前额叶皮质（DLPFC）的范式最为常见。超过一半的研究使用高密度（>32通道）系统。然而，只有44.7%的研究报告了运动校正程序，53.2%的研究未报告激活方向。只有12.8%的研究明确说明了与临床结果的联系。：尽管临床兴趣不断增加，fNIRS作为监测精神治疗反应的非侵入性神经成像工具显示出前景，但目前的证据基础受到方法学变异性和结果整合不一致的限制。越来越需要采用标准化的设计和报告方案。未来的研究还应包括纵向研究和多模态方法以提高有效性和临床相关性。
