Fang Shangping, Liu Jiameng, Yue Xingchen, Li Huan, Li Wanning, Tang Xiaoyu, Bao Pengju
School of Anesthesiology, Wuhu 241002, China.
Anesthesiology Experimental Training Center, Wuhu 241002, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2025 Aug 20;45(8):1706-1717. doi: 10.12122/j.issn.1673-4254.2025.08.15.
To analyze the differences in the prognosis of gastric signet ring cell carcinoma (SRCC) among different races using the US Surveillance Epidemiology and End Results (SEER) database and The Cancer Genome Atlas (TCGA) database.
We analyzed the data of patients with gastric SRCC from the SEER database from 2000 to 2020, and divided the patients into cohorts of whites, blacks, Asians or Pacific Islanders, American Indians/Alaska Natives according to their race. The prognosis and treatment of the cohorts were evaluated using baseline demographic analysis, Kamplan-Meier survival curve, and nomogram analysis.
We analyzed the data of a total of 2058 patients, including 8.6% blacks, 72.4% whites, 16.6% Asians or Pacific Islanders, 1.0% American Indians/Alaska Natives, and 1.4% other races. The tumor grade varied among different races, and the prevalence and survival rates of patients differed significantly across races. The differences in the white cohort were the most prominent, and all the differences were statistically significant (<0.05). Racial differences were also noted in patient management and prognosis.
There are racial differences in tumor grades and prognosis of gastric SRCC, and these differences provide evidence for optimizing clinical diagnosis and treatment strategies for this malignancy.
利用美国监测、流行病学和最终结果（SEER）数据库以及癌症基因组图谱（TCGA）数据库，分析不同种族胃印戒细胞癌（SRCC）预后的差异。
我们分析了2000年至2020年SEER数据库中胃SRCC患者的数据，并根据种族将患者分为白人、黑人、亚洲人或太平洋岛民、美洲印第安人/阿拉斯加原住民队列。使用基线人口统计学分析、卡普兰-迈耶生存曲线和列线图分析评估各队列的预后和治疗情况。
我们共分析了2058例患者的数据，其中黑人占8.6%，白人占72.4%，亚洲人或太平洋岛民占16.6%，美洲印第安人/阿拉斯加原住民占1.0%，其他种族占1.4%。不同种族的肿瘤分级不同，患者的患病率和生存率在各种族间存在显著差异。白人队列中的差异最为显著，所有差异均具有统计学意义（<0.05）。在患者管理和预后方面也存在种族差异。
胃SRCC的肿瘤分级和预后存在种族差异，这些差异为优化该恶性肿瘤的临床诊断和治疗策略提供了依据。
