Sun Feiyue, Li Xuelei, Kang Luyao, Wang Yiran, Li Hongyu, Zhu Hai
Gynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Front Oncol. 2024 Dec 11;14:1472416. doi: 10.3389/fonc.2024.1472416. eCollection 2024.
Uterine carcinosarcoma (UCS), or malignant mixed Müllerian tumor, is a cancer that include both carcinomatous and sarcomatous components, resembling endometrial carcinoma. A 55-year-old woman was admitted to the hospital with postmenopausal vaginal bleeding. Gross examination of the specimen revealed brittle tissue in the fundus and the left wall of the endometrium. Postoperative pathology revealed a mixture of well-differentiated endometrioid adenocarcinoma and osteosarcoma. The patient was never given birth, which may be relevant to the diagnosis. Literature review suggests that being nulliparous may be a significant risk factor for developing uterine carcinosarcoma.
In December 2023, a 55-year-old female patient was admitted to the hospital with postmenopausal vaginal bleeding. Hysteroscopic surgery was performed, and the postoperative pathology showed endometrial cancer accompanied by ossified tissue with necrosis. The immunohistochemical results indicated positive Estrogen receptors (ER), positive Progesterone receptors (PR), ki67 positivity at 70%, negative PTEN, mutated positive p53, focal positive Pax-8, positive SATB2, positive Cytokeratin 7 (CK7), positive EMA and positive Vimentin (Vim). The patient was diagnosed with Uterine carcinosarcoma. On December 18, 2023, the patient underwent partial vaginal resection, bilateral salpingo-oophorectomy, pelvic lymph node dissection, and a sub-extensive laparoscopic hysterectomy. Postoperatively, the patients received radiotherapy and four cycles of chemotherapy in the DC regimen. As of July 2024, laboratory and impact test results showed no tumor recurrence. The patient's disease-free survival (DFS) was seven months.
The rate of childless in patients with uterine carcinosarcoma is at a high level.
子宫癌肉瘤（UCS），即恶性混合性苗勒管肿瘤，是一种同时包含癌性和肉瘤性成分的癌症，类似于子宫内膜癌。一名55岁女性因绝经后阴道出血入院。标本大体检查显示子宫内膜底部和左壁组织质脆。术后病理显示为高分化子宫内膜样腺癌和骨肉瘤的混合物。该患者从未生育，这可能与诊断有关。文献综述表明未生育可能是发生子宫癌肉瘤的一个重要危险因素。
2023年12月，一名55岁女性患者因绝经后阴道出血入院。进行了宫腔镜手术，术后病理显示子宫内膜癌伴有骨化组织及坏死。免疫组化结果显示雌激素受体（ER）阳性、孕激素受体（PR）阳性、ki67阳性率为70%、PTEN阴性、p53突变阳性、Pax - 8局灶阳性、SATB2阳性、细胞角蛋白7（CK7）阳性、上皮膜抗原（EMA）阳性和波形蛋白（Vim）阳性。该患者被诊断为子宫癌肉瘤。2023年12月18日，患者接受了部分阴道切除术、双侧输卵管卵巢切除术、盆腔淋巴结清扫术以及次广泛腹腔镜子宫切除术。术后，患者接受了放疗及DC方案的四个周期化疗。截至2024年7月，实验室及影像学检查结果显示无肿瘤复发。患者的无病生存期（DFS）为7个月。
子宫癌肉瘤患者的未育率处于较高水平。
