Scheier Zoe A, Sturm Kassandra L, Colavecchio John A, Pradhan Apekchha, Otazu Gonzalo H
College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, New York, USA.
Genes Brain Behav. 2024 Dec;23(6):e70008. doi: 10.1111/gbb.70008.
Sensory processing abnormalities are a hallmark of autism spectrum disorder (ASD) and are included in its diagnostic criteria. Among these challenges, food neophobia has garnered attention due to its prevalence and potential impact on nutritional intake and health outcomes. This review describes the correlation between novel odor perception and feeding difficulties within the context of ASD. Moreover, this review underscores the role of odor processing in shaping feeding behaviors within the ASD population. It examines the psychophysics of odor perception in individuals with ASD and evaluates the behavioral and neurophysiological assessments conducted using novel odor stimuli in mouse models relevant to autism and wild-type mice. Additionally, we explore the mechanism on how odor novelty affects neuronal circuitry, shedding light on potential underlying mechanisms for the effect of odor novelty on ASD.
感觉加工异常是自闭症谱系障碍（ASD）的一个标志，并被纳入其诊断标准。在这些挑战中，食物新恐惧症因其普遍性以及对营养摄入和健康结果的潜在影响而受到关注。本综述描述了在ASD背景下新奇气味感知与进食困难之间的相关性。此外，本综述强调了气味加工在塑造ASD人群进食行为中的作用。它研究了ASD个体气味感知的心理物理学，并评估了在与自闭症相关的小鼠模型和野生型小鼠中使用新奇气味刺激进行的行为和神经生理学评估。此外，我们探讨了气味新奇性影响神经回路的机制，揭示了气味新奇性对ASD产生影响的潜在潜在机制。
