Dudás Ádám, Gyömöre Ádám, Mészáros Bence Balázs, Gondár Stefánia, Adamik Renáta, Fegyverneki Dániel, Papp Dávid, Otte Konrad Bernhard, Ayala Sergio, Daru János, Répási József, Soós Tibor
Organocatalysis Research Group, Institute of Organic Chemistry, HUN-REN Research Centre for Natural Sciences, Magyar tudósok körútja 2, Budapest H-1117, Hungary.
Hevesy György PhD School of Chemistry, Eötvös Loránd University, Pázmány Péter sétány 1/A, Budapest H-1117, Hungary.
J Am Chem Soc. 2025 Jan 8;147(1):1112-1122. doi: 10.1021/jacs.4c14596. Epub 2024 Dec 26.
The partial reduction of esters to aldehydes is a fundamentally important transformation for the synthesis of numerous fine chemicals and consumer goods. However, despite the many efforts, limitations have persisted, such as competing overreduction, low reproducibility, use of exigent reaction conditions and hazardous chemicals. Here, we report a novel catalyst family with a unique steric design which promotes the catalytic partial reduction of esters with unprecedented, near-perfect selectivity and efficiency. This metal-free catalytic method is ready to be placed at the disposal of chemists to provide valuable aldehyde intermediates and products and shows promise for streamlining synthetic methods in academic and industrial settings.
酯类部分还原为醛类是众多精细化学品和消费品合成中一项至关重要的转化反应。然而，尽管人们付出了诸多努力，仍存在一些局限性，比如竞争性的过度还原、重现性低、使用苛刻的反应条件以及危险化学品等。在此，我们报道了一类具有独特空间设计的新型催化剂，它能以前所未有的近乎完美的选择性和效率促进酯类的催化部分还原。这种无金属催化方法可供化学家使用，以提供有价值的醛类中间体和产物，并且有望简化学术和工业领域的合成方法。
