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聚焦YAP：解锁克服心脏再生障碍的新见解。

Spotlight on YAP: Unlocking New Insights to Overcome the Barriers to Heart Regeneration.

作者信息

Velayutham Nivedhitha, Lee Richard T

机构信息

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA (N.V., R.T.L.).

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (R.T.L.).

出版信息

Circulation. 2025 Jan 7;151(1):94-97. doi: 10.1161/CIRCULATIONAHA.124.072263. Epub 2024 Dec 26.

DOI:10.1161/CIRCULATIONAHA.124.072263
PMID:39723984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11673915/
Abstract

This editorial refers to “Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration” by Liu . and “YAP Overcomes Mechanical Barriers to Induce Mitotic Rounding and Adult Cardiomyocyte Division” by Morikawa

摘要

本社论涉及刘等人的《微管在细胞质中隔离乙酰化YAP并抑制心脏再生》以及森川等人的《YAP克服机械障碍以诱导有丝分裂变圆和成年心肌细胞分裂》

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f27c/11673915/6756693f09e4/nihms-2034921-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f27c/11673915/6756693f09e4/nihms-2034921-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f27c/11673915/6756693f09e4/nihms-2034921-f0001.jpg

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本文引用的文献

1
YAP Overcomes Mechanical Barriers to Induce Mitotic Rounding and Adult Cardiomyocyte Division.YAP克服机械屏障以诱导有丝分裂变圆和成年心肌细胞分裂。
Circulation. 2025 Jan 7;151(1):76-93. doi: 10.1161/CIRCULATIONAHA.123.066004. Epub 2024 Oct 11.
2
Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration.微管将乙酰化的YAP隔离于细胞质中并抑制心脏再生。
Circulation. 2025 Jan 7;151(1):59-75. doi: 10.1161/CIRCULATIONAHA.123.067646. Epub 2024 Aug 26.
3
YAP induces a neonatal-like pro-renewal niche in the adult heart.YAP在成体心脏中诱导出一种类似新生儿的促再生微环境。
Nat Cardiovasc Res. 2024 Mar;3(3):283-300. doi: 10.1038/s44161-024-00428-w. Epub 2024 Feb 14.
4
Two decades of heart regeneration research: Cardiomyocyte proliferation and beyond.二十年心脏再生研究：心肌细胞增殖及其他。
WIREs Mech Dis. 2024 Jan-Feb;16(1):e1629. doi: 10.1002/wsbm.1629. Epub 2023 Sep 12.
5
Gene Therapy Knockdown of Hippo Signaling Resolves Arrhythmic Events in Pigs After Myocardial Infarction.基因疗法抑制河马信号通路可解决猪心肌梗死后的心律失常事件。
Circulation. 2022 Nov 15;146(20):1558-1560. doi: 10.1161/CIRCULATIONAHA.122.059972. Epub 2022 Nov 14.
6
YAP mediates compensatory cardiac hypertrophy through aerobic glycolysis in response to pressure overload.YAP 通过有氧糖酵解介导应对压力超负荷的代偿性心肌肥厚。
J Clin Invest. 2022 Mar 15;132(6). doi: 10.1172/JCI150595.
7
Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice.心肌细胞向胎儿状态的可逆重编程可驱动小鼠的心脏再生。
Science. 2021 Sep 24;373(6562):1537-1540. doi: 10.1126/science.abg5159. Epub 2021 Sep 23.
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Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration. Yap 通过促进心肌细胞的非经典 wnt 信号促进心脏再生。
Circ Res. 2021 Oct;129(8):782-797. doi: 10.1161/CIRCRESAHA.121.318966. Epub 2021 Aug 23.
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Sci Transl Med. 2021 Jun 30;13(600). doi: 10.1126/scitranslmed.abd6892.
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